Category: Uncategorized

While Merck Sees A Nice Result, In Its RSV Vaccine Candidate, In Infants… GSK Remains The Market Leader.

~ condor ~ Leave a comment

Merck was working on a MCA vaccine like this with Moderna a few years ago — and ended up handing the rights back to Moderna, and that company continues to advance its RSV vaccine candidate.

And while this is a nice outcome for Merck’s Clesrovimab, also known as MK-1654, there are several entrenched on market franchises. So this is not likely to materially helpful, in the near term. Here’s Fierce’s fine reporting on it all:

…Moderna recently became the latest biopharma to score an approval to prevent respiratory syncytial virus (RSV), but Merck & Co. hopes to be the next in line with new data showing a monoclonal antibody reduced the incidence of RSV-related infections in infants…

“We are encouraged by these findings and look forward to working with regulators to provide a new option to help address the impact of RSV on infants and their families,” Paula Annunziato, senior vice president of infectious diseases and vaccines, Global Clinical Development, Merck Research Laboratories, said in the release.

Merck once had an RSV vaccine for adults in early-stage development, but passed it over to long-time partner Moderna in 2020 to focus on what would become clesrovimab. For its part, Moderna has powered ahead in the RSV space, scoring FDA approval for an adult RSV vaccine in May….

For now, the market remains dominated by GSK’s Arexvy shot… and yes, this is “legacy” power alley stuff.

Now you know — onward, smiling.

नमस्ते

And… Hinderaker Is A Page Behind, Again! Australia Edition…

~ condor ~ Leave a comment

I know by late tonight, Hinderaker will have seen Kamala’s launch speech, of today.

His last posting — largely gloating on Australian hard right TV… is now as stale as a can of WWII spam, left out in the Sun at Corregidor island.

Tangerine is clearly done for. Vance is now a millstone around his neck too. He’s locked into a “whyte replacement theory” claim that Ms. Harris just nuked.

Harris is America’s future… Tangerine and Vance (and Hinderaker): push forward its darkest past.

She has served notice — Tangerine’s attacks are backfiring. Calling her a DEI hire is no dart at all.

It speaks to his weakness. And she’s now free — to unleash her… strength.

The strength of our diverse, pluralistic achievement… engine.

John — your time is up. Do sit and watch.

Cheers.

Mirengoff Agrees: Tangerine Is In Deep Trouble — So Much So, That He Likely Cannot Win, Against Harris.

~ condor ~ Leave a comment

Well — that was quick.

And yes, Paul says we will still need to see the post DNC convention’s poll “bump size”. But we all know it will be large. Likely overwhelming, especially when considered next to Tangerine’s very high negatives. And Paul admits it, already.

Here’s his, in context:

…The attempt on Trump’s life has not changed him, nor was there any reason to believe it would. Trump has only one mode, and it’s the one that has made him unpopular. While fair-minded Americans will applaud him for emerging from the shooting saying “fight,” most will not applaud the way he fights. They never really have.

Trump is now the old person in the race. He’s the recycled nominee. And he’s the divider.

Harris is younger, fresher, and less divisive….

That is all true.

Trump’s style (one he cannot seem to control, even when ordered to — see the Merchan trial dates, and the Carroll ones) of mean spirited, awful, misogynistic attacks — upon women of substance — in particular… will cost him the bulk of the free-thinking GOP women, of any educational and intellectual means.

And essentially any female outside that circle that ever considered voting for him (if they are honest).

In sum, he will lose in a landslide, precisely because of WHO he has shown himself to be.

And, do consider that quite a few of the middle to liberal fence sitters will want to truthfully say they elected the first Black woman President. [Just as with Mr. Obama in the landslide of 2008.]

Trump is dead in the water, now.

P E R F E C T.

So — This, Too… Will Get Sorted Out At The Supremes… YAWN: Latest Eighth Cir. Nonsense.

~ condor ~ Leave a comment

Last week, a summary, one sentence order from St. Louis — out of the Eighth Circuit again put the brakes on the latest student loan forgiveness measures of this Administration.

The Supremes will ultimately rule (in about the seventh month of the 47th — Harris — Presidency!) that the program was a lawful exercise of Executive Power, under long-standing Congressional Acts. These GOP kids really know how only… to waste their own time.

Now, on the real news of the weekend — I had actually hoped that Mr. Biden would have resigned two years ago, and given Kamala Harris about two years of track record to run on, since we all knew the felon-in-chief was going to… try to run again. I (naively, it turns out) believed the old line GOP would never nominate a guy with now over $500 million in fraud judgments tacked to his back, and 34 felony convictions entered against him — with more, and more serious ones… yet to come.

I was wrong. These people know no… shame.

Yes, I find the way it ended… distasteful, but as a nation, we cannot run even a small risk that this walking crime spree is again at 1600 Penn. — so some eggs had to be broken. I admire the grace and aplomb with which Mr. Biden has always conducted himself. He is the embodiment of a peaceful transition of power (like Washington, that — “One Last Time” — in the verses of Hamilton — note how prophetic that bit of the reel, at the 2:10 mark appears, from the White House — of about 2016).

Now — I just chuckle that the GOP/MAGA thinks that making fun of the way Kamala Harris laughs. . . is going to sway the middle (a tiny fraction of undecideds) TO VOTE FOR an obvious felon, fraudster, sexual predator and… yes, demented old man — losing his marbles. The exact knock he falsely laid at Mr. Biden’s feet now applies to him — in spades. He’s the geriatric, cranky, bed-wetting candidate — with no moral compass.

I predict he will suffer a sudden, debilitating flare up of bone spurs — and bow out of all debates with Kamala Harris. She will mop the floor with his toupée, if he is dumb enough to keep the debate dates.

Thank you Mr. Biden — you were not perfect, but you served your nation admirably. Thank you — and onward to stamping out MAGA — at the ballot box, by over 10 million votes, net — and winning PA, MI, WI and probably even Arizona and Nevada. Without at least five of these, Tangerine cannot win, on pure electoral college map math (looking at the rest as pretty safe safe red or blue states, respectively).

Go — and be excellent to one another. Fight for the future of our relatively fragile but pluralistic dream. Out.

नमस्ते

Hinderaker: Not Up On The Latest, Again. It’s Kamala Harris — For The Win!

~ condor ~ Leave a comment

Well… in all likelihood, the Tangerine / Vance ticket just… lost 2024 — in a landslide.

Mr. Biden has handed the mantle to Kamala Harris. We will see the first woman of color President in US history, come November.

The notion that the remaining undecideds will choose a convicted 34-time felon — who has $500 million in fraud judgments tacked to his name — over a very bright, street fighting debater about only two thirds his age… is simply not credible — regardless of color or gender. Tangerine just became the mean ole’ pop pop he’s been demonizing.

My first prediction is he will claim his bone-spurs have flared up, and he cannot debate her later in the cycle, or ever. If he shows up, she will mop the floor with his awful toupee.

So John’s charts are now meaningless, except that they do accurately reveal how poorly Trump will do in swing states — against a vibrant younger opponent: he cannot win in Michigan, Wisconsin, Pennsylvania or Arizona now. Probably not in Nevada, either.

He’s done — if our nominee is Kamala Harris.

But Hinderaker had this much right — pre- the Biden news of the day… even if he’s two paragraphs behind what’s known, as I say:

…If the Democrats nominate someone else — I think it almost has to be Kamala Harris, although some disagree — he could be in trouble. It is true that she is a lousy candidate, but compared to Joe Biden? I think a fair number of Democratic and swing voters would move her way, making the election too close to call [Nope, a landslide for the Democratic Party. It is now hers to walk away with]….

Onward — grinning. John got what he wished for — now he has a geriatric crook at the top of his ticket.

See ya’ in the funny papers, son.

[What the GOP oppo machine did to Joe is awful. But it is already time to move forward swiftly — this election is too important to do otherwise. Out.]

Paul… Finally Admits: Tangerine Shoots HIMSELF, With Every Interminable Hateful Speech Now.

~ condor ~ Leave a comment

He put this thesis behind a paywall, tonight — but it is obvious that’s what he thinks. At least (unlike Hayward & Billingsley)… he concedes reality.

Tangerine is a terrible speaker — and increasingly, he drones on so long that he loses even his core supporters.

I think once a few weeks pass, the polls will start to show his shot… such as it is, has come — and gone.

No one with a working brain wants a felon in the highest office.

Period. No need for a paid subscription. That’s a “Captain Obvious” truth.

Out.

In Coventry, The Union Vote Came Up Just A Mere Handful Of Votes… Short. Against Amazon Tactics — And 10 Hour Shifts…

~ condor ~ Leave a comment

I admit, I couldn’t bring myself to write about this at mid-week, with all the other awful news… spilling out onto the docks, on this side of the ocean. Ugh. But we are done with the QVC hosting from Milwaukee… finally [he kept people awake, or asleep more likely, on the East Coast well after midnight Thursday, into Friday morning, with a hateful, vain and utterly disjointed rant… of over 90 minutes, and 16,000 words. Wow].

So I will note it, now — as the fog lifts.

[Prior backgrounder of mine, here.] And now, without any additional ado, here is the NYT, on it all — from mid-week:

…A fight to form the first union at an Amazon warehouse in Britain came to an end this week, as organizers of the effort fell short by just 28 votes.

About 2,600 employees at the warehouse in Coventry, in the Midlands of England, took part in a ballot for union recognition, which would have forced Amazon to negotiate collectively with the bulk of workers there over working conditions, as well as pay, holiday and other benefits. More than 3,000 Amazon workers were eligible to vote.

But in the end, the effort failed, with only 49.5 percent voting in favor in a poll approved by the Central Arbitration Committee, a government body. It is the closest any Amazon center in Britain has come to being unionized.

The results come amid accusations by GMB, a nationwide union, lawyers and some workers that the American tech giant had been heavy-handed in its efforts to discourage unionization. Amazon has a history of pushing back against union movements. In the United States, only one warehouse, on Staten Island, has a formally recognized union. A labor union in Germany has been trying to get collective bargaining powers for more than a decade.

The vote fell “agonizingly short” of a majority, said GMB, which counts Amazon employees among its 500,000 members from various occupations. “Amazon bosses have created a culture of fear for low-paid workers trying to improve their pay, terms and conditions,” said Stuart Richards, an organizer at GMB.

GMB cannot make another bid for formal recognition for three years, but workers are continuing a legal claim that accuses Amazon of illegally trying to induce employees to quit the union. Workers claimed the company pressured them to attend several seminars that suggested the union would jeopardize employees’ pay and benefits. They also said the company liberally displayed QR codes to make it easy to cancel union membership, which lawyers said was a breach of British law that prohibited companies from making offers to employees to not be in a union. Amazon said that attending the meetings was voluntary and that GMB also held meetings in the warehouse….

Agonizingly short. But we will keep our head up, because this very same labor discontent in Britain largely forced a sea-change in British government, just this summer — a month ago. Onward, with hope just the same — Mr. Bezos cannot resist the arc of history — toward progress… forever. He cannot beat the tide, in due course. Across the pond, or here.

नमस्ते

So… I Received A Likely “False Flag” Mailing…

~ condor ~ Leave a comment

I’ve intentionally obliterated the call to action it contained (at right).

Until more meetings take place, between Senate leaders and the Vice President… I view the mailing as singularly… non-helpful.

Which is why (given the lack of a track record — for this just formed PAC, at 300 Vesey in NYC) I find myself wondering if it’s a GOP generated piece of garbage.

Smells… like… John Hinderaker’s “think tank”.

But we will let it age a few weeks before we make a formal accusation.

Onward.

Hinderaker Should Wonder: Did Tangerine Suffer A Brain Injury, In The Saturday Dog Pile?!

~ condor ~ Leave a comment

Look — Tangerine was never a remotely good public speaker.

He’s always been… a “word salad” man, just tossed vigorously — with lots of fatty white dressing.

But (having sped through his 90 minutes, 16,000 words of… gibberish), I must say — both John and I think he may well have been… concussed, by the bouncing weight of four agents on his head and scalp….

And at his age… this could rapidly… deteriorate — in permanent fashion.

Much of what he said was unintelligible… and what was on the surface understandable… was littered with non-sequiturs.

Tangerine should now deeply fear a return debate date — against Kamala Harris this time (if that’s where this weekend’s cards fall).

She will… bury him.

And… John is also correct — from here on… Trump’s gonna’ look and sound… like your pop-pop.

The GOP was idiotic in stoking a narrative of disarray and “confusion” as to the Biden camp — now they face an opponent who will win over Baby-T — by 12 to 15 points, in the general — in Veep / Pres. Harris.

Reap the whirlwind, boys.

Out.

Tangerine Tonight (Milking It) Said “He Shouldn’t Be Here”. Right; But Not For THAT Reason…

~ condor ~ 1 Comment

Tangerine shouldn’t be here… for dozens of solid reasons — but most of all, Ron Reagan’s party, and Ike’s party and Bush’s party (and even Nixon’s party!)… would NEVER have considered nominating a convicted felon with over $500 million in court fraud judgments tattooed to his name, for a return to 1600 Penn.

Never. [Nope. Just the regular Penn. or a Club Fed., most charitably.]

That this GOP crowd of 2024 lustily cheers a walking crime spree, and serial sexual predator… is purely… Orewellian.

So, no, you’re right “Mr. Apprentice” — you shouldn’t be here, in Milwaukee tonight. You should be… in FCI Allenwood (Low). Serving time — for 34 felonies.

And you truly will be, in time… once you lose in November. Maybe even before November.

If Americans vote for this crook… he’ll fall apart before the first year is out. Weekends in jail will do that to even a young, fit man.

Out.

Who are these deplorable humans who think their God wants them to vote for a felon — and a man who’ll hold the Bible upside down… (while ordering the beating of protestors in a historic DC church yard) — and sells his own black Sharpie-inked autograph, on cheap copies of the Bible, at $60 a pop?!

Who?!