Fifty Years On, For Norman’s Iridescent Gem Of A Debut — And 56 Years, Celebrating Earth Day… Seems Appropriate.

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I think I’ve mentioned a few times here, over the years, that in many ways… my childhood was a mash-up of what was written by Norman, in A River Runs Through It, and slightly modernized by Stephen King’s “The Body” / Stand By Me. We fly-fished less than Norman, but got caught up in a lot of the same shenanigans, my brothers and I.

Our soundtrack / backpacking in the national forests of the High Rockies — mostly at the headwaters of the Arkansas… was definitely a AA battery powered tinny transistor AM Radio tuned to KOMA, out of Oklahoma City [mostly Soul and Funk]… the only station with the wattage to clear the Continental Divide.

And so, most of my very pro-environmental thoughts began… on those rivers, and in those canyons. The mountain-tops of 14,000 plus feet, too. Here’s Norman [slightly modified], then:

“…Now nearly all those I loved and did not understand when I was young are dead, but I still reach out to them.

“Of course, now I am too old to be much of a fisherman, and now of course I usually fish the big waters alone, although some friends think I shouldn’t.

Like many fly fisherman in [the Rockies], where the summer days are almost Arctic in length, I often do not start fishing until the cool of the evening. Then in the Arctic half-light of the canyon, all existence fades to a being with my soul and memories and the sounds of the [Arkansas] River and a four-count rhythm and the hope that a fish will rise.

“Eventually, all things merge into one, and a river runs through it. The river was cut by the world’s great flood and runs over rocks from the basement of time. On some of the rocks are timeless raindrops. Under the rocks are the words, and some of the words are [mine, to you]….

I am haunted by waters….”

Smile — do go be excellent to one another — and be excellent to the mother of us all — the Earth. Onward.

नमस्ते

[U] DoJ: Weaponizing Criminal Law — Against Investigators, Of White Supremacy Groups…

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For over a decade, John Hinderaker has complained that the Southern Poverty Law Center had labeled his blog… a racial hate site.

My reaction? “One cannot libel… garbage by saying it… stinks.

[Truth is an absolute defense under US law, that is.]

Minor update @ 10 pm EDT — no surprise here at all Bill G. over at Powerline gets the story completely wrong… He has no idea what he’s talking about. Yet he blathers on and on… that the KKK itself was/is a “hoax.” What a stupid tool.

Bill conveniently fails to mention that his boss, Hinderaker — regularly complained about the “unfairness” of being labeled as a hate site by the SPLC — for about three years from 2016 to 2019. John didn’t think they were an hoax at all. End, silly updated portion.

Tonight, it seems John has gotten Kash Patel, Todd Blanche and the boys… to indict the SPLC — on preposterous charges of not being truthful with their donors.

The claim is that SPLC was required (under federal criminal laws) to tell its donors that some small part of the organization’s funds would be used to recruit and keep… “double agents” / informants… inside hate groups like the various KKK chapters and the “Unite The Right” a-holes, who attacked peaceful demonstrators in 2018, in Charlottesville, VA — during Trump 1.0.

It is obvious that no crime occurred (and it is obvious why one would not out its double agents here — on pain of likely death!), but Todd Blanche’s homie-indictments have been handed up, tonight. They will be shortly dismissed — by right thinking USDC Judges.

This is simply Trump’s ongoing demonization campaign, against any organization that criticizes him and his minions, as racists.

Do note that organizations on the right including Tom Fitton’s JudicialWatch, and Kevin O’Keefe’s “fraudulent left group” Project Veritas, were never charged (under Messrs. Biden or Obama), after using organization funds to run “double-agent” programs against ACORN, among others. [And they lied on video about what they were doing.] No, they were caught spending donations on orgies and the like — that’s what ended them.

They are bankrupt, but not… in jail.

Onward, resolutely.

Well — Not Every Game Features… A Grand Slam. Eisai And Merck See Another Miss, On Their Combos, In Advanced Renal Cell Carcinomas…

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Regular readers here will recall that in August of 2023, the same combo posted some disappointing results in head and neck cancers. [But the combo remains quite useful in uterine cancers.]

Yes — to be fair, that is the way of things — not every combo trial will be a home run. The strides that we’ve made in about a decade, in treating previously dire cancers… is nothing short of revolutionary, with Keytruda® (pembrolizumab), primarily — just the same.

And to be certain, each of the therapies is a mega blockbuster in its own rights — so I think the NYSE reaction (off ~4%, as to Merck, particularly) is decidedly over-blown.

This is all… mostly fine-tuning, where and how to deploy these wonder drugs — in various combinations, for various cancers. Here’s the latest, in any event:

…Merck and Eisai today announced results from the Phase 3 LITESPARK-012 trial evaluating combination regimens for the first-line treatment of patients with advanced clear cell renal cell carcinoma (RCC). The trial evaluated the triplet therapy of KEYTRUDA® (pembrolizumab), Merck’s anti-PD-1 therapy, plus LENVIMA® (lenvatinib), the orally available multiple receptor tyrosine kinase inhibitor (TKI) discovered by Eisai, plus WELIREG® (belzutifan), Merck’s first-in-class, oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor. The study also evaluated MK-1308A, the coformulation of KEYTRUDA and quavonlimab, Merck’s investigational anti-CTLA-4 antibody, plus LENVIMA. Both combination regimens were compared to KEYTRUDA plus LENVIMA for these patients.

At a pre-specified interim analysis, the combination regimens did not meet the dual primary endpoints of progression-free survival (PFS) and overall survival (OS) for the first-line treatment of patients with RCC compared to KEYTRUDA plus LENVIMA….

This is how real life science progresses — find the blind alleys, and then don’t go back down them. That’s the iterative process we all must endure — to make truly lasting, evidence based advances — in oncology. Onward — with bby grrls at the park, again this evening — woot!

नमस्ते

The Vast Economic Harm Caused By Warrantless ICE Raids — Just In Minneapolis/St. Paul, Alone: New Report.

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The twin cities estimate, via an independent study, that over $650 million in lost revenue was directly attributable to the disruptions, street barricades and general fear engendered by the ICE surges in Minneapolis, over those nine weeks. You may read that (all eight pages) as an exhibit to the amended complaint, in the class action now working its way throught the federal court there. [Prior backgrounder, here.]

That is. . . staggering — but personally, I want to highlight the way businesses and others have reported that ICE agents treated them. That is. . . staggering — but personally, I want to highlight the way businesses and others have reported that ICE agents treated them. [I’ve used the St. Paul version, below, but here is the Minneapolis one, for a complete record.] Most of all, look at that last line: not even one person was ever shown a judicial warrant, prior to ICE trespass, into private property — and/or arrests. Damn:
Most of all, look at that last line: not even one person in st. Paul was ever shown a judicial warrant, prior to ICE trespass, into private property — and/or arrests. Damn:

…Agents entered a non-public area of their business without consent | 12.8%

Agents questioned their workers about their immigration status | 7.4%

Agents detained or arrested workers inside the business | 3.6%

Agents questioned customers about their immigration status | 19.1%

Agents detained or arrested customers inside the business | 0.9%

Agents presented an administrative warrant | 2.3%

Agents displayed weapons inside the business | 3.6%

Agents presented a judicial warrant signed by a judge | 0.0%….

This is insane. The American people deserve better, from their elected administration, at the federal level. It is high time to vote them… out. Onward.

नमस्ते

USDC Judge Dolly Gee Entered A Clear Order That Kids Grabbed By ICE Or DHS Shall Not Be Held In Hotels More Than 48 Hours. The Government Says She Didn’t Mean It — Wants Us To Blink — At Reality.

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These are small children — frightened — and more than occasionally, alone until a relative can be found.

The AUSAs, on Miller’s likely orders, are filing sworn statements from ICE officials, saying certain things simply “cannot be done” promptly — or at all. [But they offer zero proof of actual impossibility.]

One of the stupidest things they say cannot be done — is listed as “due to a likelihood of fleeing“.

First, this misstates the law — and it blinks unconvincingly, at the actual facts. Seven year olds are not likely to flee a hotel holding them in a strange city under cover of night — especially if they are alone. But that’s what these affidavits falsely assert: that the law requires DHS not to grant them release to relatives.

There is no such law. There is only Tangerine 2.0’s black Sharpie scribble, for that proposition — the Congress, by statute said the opposite: they are to be promptly freed (to their family- or other- guardians) — so as not to suffer added trauma.

[Do recall that the lil’ guy (age 5) grabbed in Minnesota — was shipped off to El Paso, Texas (without any hearing or intervention), and it took two weeks to get him back home, early in 2026.]

These people are… simply monsters. Out.

नमस्ते

Crime Often Will Go Down… With A “Gestapo, In Town”, John.

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Yeah Hinderaker… the trains ran on time too — when Hitler imposed martial law in Berlin.

But that is nothing to celebrate — as John has, this evening.

We should pride ourselves (as a nation) on being a “civil” democracy, policed by civil forces, restrained by Constitutional law.

In the main, the people ought to be free… to act foolishly, but not criminally.

Trump (in version 1.0 and 2.0, too) has inverted that pyramid — trampling all of our civil rights, in the process.

I get it: Hinderaker prefers the “original German”.

I do not.

And most Americans do not.

Watch the mid-terms, chump.

Out.

Lilly To Pay Up To ~$7 Billion, To Acquire All Of Kelonia, And Its CAR-T BCMA-Targeting KLN-1010 Phase 1 Candidate…

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This just might be a case of buying the whole cow, when perhaps only buying a few gallons — of the milk — would have sufficed.

But if the CAR-T KLN-1010 “milk” candidate is as good as advertised, this may have been the only deal Kelonia management would accept: “buy the whole cow” — and get the BCMA targeting goods, along with it. That is, the Kelonia team may well have been in a position of strength, and the perhaps as much as ~$7 billion price tag reflects it. Here’s the latest, from Fierce:

…Eli Lilly is picking up its second in vivo CAR-T company of the year, paying $3.25 billion in upfront cash for Kelonia Therapeutics and its phase 1-stage myeloma therapy.

Kelonia is a lentiviral vector delivery specialist [with a] lead program [that] BCMA-target[s] in vivo CAR-T. [The candidate is dubbed] KLN-1010 [by Kelonia]….

The Boston-based biotech read out a slice of data from a phase 1 trial in relapsed/refractory multiple myeloma last year that demonstrated a 100% minimal residual disease-negative response rate in the first four patients evaluated….

Wow — that’s a small data set — yet, $7 billion? I gather Lilly’s CAR-T shopping spree, in the oncology suite, continues apace [and spending some of that GLP-1 blockbuster revenue]. Smile — onward, into the sunshine in the steel and glass canyons, now.

नमस्ते

Japanese Markets Are Now Open (Monday, There) — And Brent Crude / Barrel Has Spiked 6%, As Tangerine’s Promises Are Again… Empty Tanks.

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This is going to be the way of things, for quite a while — it would seem.

Tangerine well-knows these crude oil-prices and therefore, US retail gas prices… are going to kill the GOP candidates, at the mid-terms. So he keeps making happy talk, about grand deals… that mostly don’t exist. And won’t exist — as he’s given the people in charge in Iran… ample reason to make him look even more foolish than he himself looks.

So buckle up, for more retail increases — in the price of… everything, that needs to be flown, or trucked — anywhere, into or around, even — in the US (via a gas or diesel engine). Here is the latest from Tokyo, Monday mid-morning their time:

…Brent rose to $96.04 on April 20, 2026, up 6.27% from the previous day. Over the past month, Brent’s price has fallen 3.90%, but it is still 44.95% higher than a year ago, according to trading on a contract for difference (CFD) that tracks the benchmark market for this commodity. This data was last updated on April 20 of 2026….

D A M N. Our economy won’t work with oil above $90 a barrel, into the summer. It is broken. Damn — thanks Trump.

नमस्ते

Hinderaker Thinks The 14th Am.’s Plain English Is “A Huge Problem”. But He Rejects… Amending It. Huh.

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So, yet again, John Hinderaker would tell us that “the interpretation” of the plain English of the Fourteenth Amendment… is a disaster, of monumental proportions.

He apparently thinks we cannot read the language. This is no “interpretation” — this is what the black letters say, in English: “born here; citizen here.”

Likewise, John well-knows that the only legitimate path to changing that… is a Constitutional amendment. And he also well knows such a thing could never garner the 2/3rds majorities needed, to even begin that process.

So he hopes for a judicial coup d’etat. One that will never come. [And of course, without violating that clause, the GOP is increasingly unlikely to win very many more national elections. So he… proposes… cheating. Y A W N.]

This is John — demand that everyone (excepting him!) play by the rules, established some 150 years ago.

Hinderaker? He will just keep up his vainly unavailing, nigh impotent “forum shopping“, for crooked judges.

What a pig.

Out.

Voyager 1 Is Again Shutting Down Some More Measuring Instruments — To Prolong The Mission’s Life — Now At A Half-Century…

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We have long covered these twin “grand-daddies” — of interstellar flights [Voyager 1 and 2]. We know it takes 23 hours for commands to reach the craft, at the speed of light, now. That’s pretty far out — out, there. And we hope it can all continue, to be certain. But we are aware that the craft was designed to last only five years, and it is now approaching ten times that age.

Here is the latest, from NASA:

…On April 17, engineers at NASA’s Jet Propulsion Laboratory (JPL) in Southern California sent commands to shut down an instrument aboard Voyager 1 called the Low-energy Charged Particles experiment, or LECP. The nuclear-powered spacecraft is running low on power, and turning off the LECP is considered the best way to keep humanity’s first interstellar explorer going….

The LECP has been operating almost without interruption since Voyager 1 launched in 1977 — almost 49 years. It measures low-energy charged particles, including ions, electrons, and cosmic rays originating from our solar system and galaxy. The instrument has provided critical data about the structure of the interstellar medium, detecting pressure fronts and regions of varying particle density in the space beyond our heliosphere. The twin Voyagers are the only spacecraft that are far enough from Earth to provide this information. . . .

During a routine, planned roll maneuver on Feb. 27, Voyager 1’s power levels fell unexpectedly. Mission engineers knew any additional drop in power could trigger the spacecraft’s undervoltage fault protection system, which would shut down components on its own to safeguard the probe, requiring recovery by the flight team — a lengthy process that carries its own risks.

The Voyager team needed to act first.

“While shutting down a science instrument is not anybody’s preference, it is the best option available,” said Kareem Badaruddin, Voyager mission manager at JPL. “Voyager 1 still has two remaining operating science instruments — one that listens to plasma waves and one that measures magnetic fields. They are still working great, sending back data from a region of space no other human-made craft has ever explored. The team remains focused on keeping both Voyagers going for as long as possible….”

Now you know — onward, smiling into the sunshine. So many things for which to be grateful, indeed.

नमस्ते