Hey Hinderaker: “An Animal Is — As An Animal… Does.”

As ever, John offers no reasoned defense of the death penalty machinery today.

He simply tosses bloody, rotting red meat into the square, hoping for a wild mob to go… berserk.

He sniffs that he “might not watch” if Whiskey Pete Hegseth decides to execute the man on live TV — by firing squad.

Thus, he concedes the larger and more important point: this entire move is “bread and circuses” — like in the waning days of ancient Rome.

It all simply plays to the least common denominator — among the unwashed masses.

The whole shit show is well beneath modern civic dignity.

Thanks, John, for reminding us of that.

[I’m in the air now — on a plane back to Chicago as I type this… Forgive any typos.]

Out.

[U] Exceedingly Tough News: Bundibugyo / Ebola Fatalities Have Lept The DRC Border; Man In Nairobi Has Died — At Least 66 People Need To Be Monitored…

The fastest spreading Ebola outbreak in modern history just got significantly worse. It is now known to be present in the bustling capital of Kenya — with a fatality, and potentially 70 or more people exposed to Bundibugyo. [You may recall that in June, Tangerine 2.0 tried (without success) to force Kenyan authorities to build a “leper colony“ / tent city — to quarantine / house any US Citizens in Africa suspected of Ebola exposure. What a feckless putz.]

Here’s the latest — from Minnesota’s CIDRAP:

…Kenya said 10 people are in quarantine after a Kenyan man died in Nairobi on Monday from the Bundibugyo strain of Ebola currently circulating in the Democratic Republic of Congo (DRC). Officials also said they are attempting to trace 57 other case contacts.

The man, who had lived in DRC for 11 years, arrived in Kenya over the weekend. He had been sick for one month before traveling to Nairobi via a flight from Uganda. Kenyan officials say they do not know why health screenings failed to detect the man in either the DRC, Uganda, or at the Nairobi airport….

[Subsequent Update: It turns out that the] patient travelled by road to Kampala, Uganda, before flying to Nairobi, arriving on October 3. The patient was isolated in hospital and tested positive for the virus. Despite supportive treatment, the patient died on October 5, the WHO said….

The most recent update from the DRC shows 8,665 confirmed and 4,178 deaths, with a case-fatality rate of 48.2%….

Very discouraging, indeed. But onward, just the same. [I’ve momentarily broken radio silence, and posted this one, from about 9,000 feet, on the road — it seemed a significant development. Smile.]

नमस्ते

Vaxcyte’s OPUS-1 Clinical Trial Posts “Very Near Best Case” Scenarios — For Its Pneumococcal Conjugate Vaccine Candidate: Merck And Pfizer Beware!

Its stock was in the mid-$50s on Friday. This morning, it opened just over. . . $90.

The candidate is besting Merck and Pfizer on some viral strains, and at least matching them on all others. This is, indeed, a big deal. Here’s the latest — from BioSpace’s reporting:

…Vaxcyte’s investigational pneumococcal conjugate vaccine has achieved “near best-case scenario” data in a late-stage trial, matching existing shots on certain vaccine strains and beating them on others. The results sent the biotech’s shares up by more than 50% as investors welcomed a readout that could inject Vaxcyte into an $8 billion market.

VAX-31 met Pfizer’s existing pneumococcal conjugate vaccine (PCV) Prevar 20 and Merck’s Capvaxive on all 28 serotypes that one or both vaccines address, according to a Monday release. Vaxcyte’s option was superior to both vaccines on three unique serotypes. The Phase 3 trial met the co-primary endpoints that assessed non-inferiority of VAX-31 versus the marketed vaccines.

“[It] will be very difficult to refute that VAX-31 is showing best-in-class PCV potential here in this $8Bn+ (and growing) market,” Mizuho wrote in a Monday morning note.

Leerink Partners dubbed the readout “highly impressive….”

Now you know and this is excellent news for seniors most at risk from these viral vectors. Onward — to catch a jet outta’ Midway. Smile… keep it spinning in good karma whilst I am away.

नमस्ते

Gee, John Hinderaker — Most People We Know Love It In & Around Minneapolis…

Tonight, John would tell us that, based on some specious polling that his dumb think tank did, a “majority” of people in Minneapolis don’t like living there. And feel the city is going “in the wrong direction”.

I’ve always thought that was a particularly stupid poll question to ask. For whatever that might mean, the answer would differ, and differ radically — depending on what you define as the ”right”direction. And of course that’s never specified. And that my friends — is precisely how dishonest pulling is constructed.

But putting to the side the problems with John’s stupid little poll questions, I just want to note for the record that we have dozens of good friends who have lived most of their lives in and around Minneapolis — and they continue to love living there — the same way we love living in Chicago.

And we always enjoy visiting just as they enjoy being on visits down here in Chicago.

So personally, I’d say his supposed poll is little more than birdcage liner.

Out.

A Guy Who Presided Over At Least Five Botched “Humane” Executions — Across Three States, And Over A Decade… Is Out Of Work. Good Riddance.

Certainly, this Frank Strada is rightfully out of a job — but so too should be all Chief Executioners, nation-wide, regardless of the gruesome, depraved and turgid methodology selected, for killing our fellow citizens (or more than occasionally, for failing to do the job).

The whole exercise is well-beneath a civilized society — regardless of whether some in our number still feel the need to bray at the full Moon, late into the nights. [The woman condemned in Tennessee this week remains in an agonizing fugue state, lingering between life and death — having never regained consciousness. Severe brain damage is almost certain to have occurred.]

So here, again (I’ve posted this dissent before, here), is what I regard as the best reasoning — from a dissent Justice Harry Blackmun penned in Callins v. Collins, 114 S.Ct. 1127, 1128-38 (1994), now over 33 years ago:

“…From this day forward, I no longer shall tinker with the machinery of death. For more than 20 years I have endeavored — indeed, I have struggled — along with a majority of this Court, to develop procedural and substantive rules that would lend more than the mere appearance of fairness to the death penalty endeavor. Rather than continue to coddle the Court’s delusion that the desired level of fairness has been achieved and the need for regulation eviscerated, I feel morally and intellectually obligated simply to concede that the death penalty experiment has failed.

It is virtually self-evident to me now that no combination of procedural rules or substantive regulations ever can save the death penalty from its inherent constitutional deficiencies. The basic question — does the system accurately and consistently determine which defendants “deserve” to die? — cannot be answered in the affirmative. It is not simply that this Court has allowed vague aggravating circumstances to be employed, see, for example, Arave v. Creech, (1993), relevant mitigating evidence to be disregarded, see, for example, Johnson v. Texas, (1993), and vital judicial review to be blocked, see, for example, Coleman v. Thompson, (1991). The problem is that the inevitability of factual, legal, and moral error gives us a system that we know must wrongly kill some defendants, a system that fails to deliver the fair, consistent, and reliable sentences of death required by the Constitution.

It is the decision to sentence a defendant to death — not merely the decision to make a defendant eligible for death — that may not be arbitrary. While one might hope that providing the sentencer with as much relevant mitigating evidence as possible will lead to more rational and consistent sentences, experience has taught otherwise. It seems that the decision whether a human being should live or die is so inherently subjective — rife with all of life’s understandings, experiences, prejudices, and passion — that it inevitably defies the rationality and consistency required by the Constitution.

Perhaps one day this Court will develop procedural rules or verbal formulas that actually will provide consistency, fairness, and reliability in a capital-sentencing scheme. I am not optimistic that such a day will come. I am more optimistic, though, that this Court eventually will conclude that the effort to eliminate arbitrariness while preserving fairness “in the infliction of [death] is so plainly doomed to failure that it — and the death penalty — must be abandoned altogether.” Godfrey v. Georgia, 446 U.S. 420, 442 (1980) (Marshall, J., concurring in the judgment). I may not live to see that day, but I have faith that eventually it will arrive. The path the Court has chosen lessens us all. I dissent….”

Onward, in the morning, to catch a jet — into the high Rockies, to spend another precious week with my now 92 year old Alzheimer’s suffering mom. These gloriously fiery Fall Aspen colors are what she’s spent her whole life working, and saving for — and now she shall have it, whenever she’s able. Smile — life… not the cold, mum, raw maw of death, is the point… of life, afterall.

Largely off-grid for a week.

नमस्ते

Official DRC Ebola Death Toll Crossed 4,000 Today. Actual Totals Are More Like… 6,000. Disheartening.

Not surprising. Just discouraging. Last time (during the Biden Admin.), the dying ended with four people in DRC. We are a thousand-fold worse, under Tangerine’s gutting of international aid sources for public health. Dammit.

Here’s the latest, even as that local political leader (slain for advocating safe Ebola burial practices — in Butembo) was buried, just yesterday:

…Congo’s Ebola outbreak has now recorded more than 4,000 deaths, authorities said as they struggle to contain the spread of the virus.

The latest figures were released by the health ministry on Thursday. They show that 4,018 people have died from among 8,300 confirmed cases in what has become the fastest-growing Ebola outbreak in history.

More than 2,000 patients have recovered from the disease, the Reuters news agency notes….

Now you know — and my Northwestern Wildcats are putting on a Friday night show in their sparkling new stadium here tonight — up 24-7 at halftime on the formidable Penn State squad. Let’s hope it lasts! Onward. [And the ‘Cats did wallop my CU Buffs whilst I was on the French part of my vacay, in Nice. Heh.]

नमस्ते

I Am Cribbing Shamelessly From EW This Morning. Let’s Take A Look At Who All Attended Tangerine 2.0’s Tech Summit / Dinner… How Ironic!

Properly, EmptyWheel gets credit for the list — hers is replete with expansive bios on each name — and each coming here mostly as refugees (some without proper papers).

I will simply list them — for irony’s sake. Most are from what Trump calls “sh!thole countries”. What an a$$. Here’s the list — fully 11 of the 19:

…Shyam Sankar

Chamath Palihapitiya

Satya Nadella

Lisa Su

Hock Tan

Jensen Huang

Elon Musk [South Africa — worked unlawfully here, on an expired student visa]

Sundar Pichai

Sanjay Mehrota

Nikesh Arora….

Now you know. Each one, a shitholer — but now as captains of industry — they are Tangerine’s best billionaire buddies. This is no judgment of them — I judge… him. He is a malign monster — nothing more. A divisive opportunist.

नमस्ते

Deplorable: Tennessee Utterly Botches Another “Lethal” Injection Of Ms. Pike.

[Note: This item was originally published at another of our properties, after 1 am this morning.] These insane, malignant sprints to kill… are worse than the lawlessness seen in the Old West — and perhaps even in the old Colosseo, in biblical Rome.

The state of Tennessee has waited some 30 years to put her to death. What would a few more weeks matter? As we mentioned this afternoon, she had asked, as a show of the depravity of our society’s use of the death penalty, to be executed by firing squad.

We can be sure of one thing, as midnight rolls past: she would be dead by now if the state had listened to her. As it is, leaving her in a permanently vegetative state is absolutely cruel and unusual punishment, as prohibited by the eighth amendment.

Here is the latest — but what on Earth is wrong with our society at the moment?

…A Tennessee woman convicted of murder survived two doses of lethal injection on Wednesday night before state officials suspended the execution and had her taken to a hospital for medical care, her lawyers said.

It was the second botched execution in the state this year.

The apparent failure came after dueling court rulings delayed the execution of the woman, Christa Pike, by about nine hours. The state had raced to go ahead with the execution before the day ended and to avoid having to reschedule.

In a pair of emergency legal filings, Ms. Pike’s lawyers said that while two syringes of pentobarbital, the lethal drug, had been administered, Ms. Pike had not lost consciousness. She still had a heartbeat, they said, and was audibly snoring.

It was not immediately clear what went wrong with the administration of the drugs, or what Ms. Pike’s medical condition was. In a statement late Wednesday, her lawyers said that she was at a nearby hospital but that they did not know her condition. Tennessee officials confirmed to a federal judge late Wednesday that Ms. Pike was receiving medical care….

We are nearly completely alone in the 21st Century in still conducting executions. We are absolutely all alone in seeing a single state fail to execute two inmates in under a year.

It is repugnant to civilized society that we are putting people to death in the first place, but then to fail to complete the job, and likely leave her as a brain-dead vegetable, is something not even cave dwellers of 100,000 years past would have accepted… as an outcome.

Shame on us. We are scarcely any better than a 1920s lynch mob, tonight. Nor any better than the failed Pazzi attack (hired out by Pope Sixtus IV), inside the cathedral, at Sunday Mass — in 1478, upon Lorenzo de’Medici. He was stabbed in the neck but survived — his little brother died on the cold marble altar, of stab wounds. Failed attempts, all — and Pazzi was hung, and disemboweled for the effort. [Maybe that same fate ought to befall the Tennessee state prison guards?] Out.

नमस्ते

Merck Posts Encouraging Phase 2b Results — For The Prometheus-Acquired Tulisokibart, In Moderate To Severe Hidradenitis Suppurativa…

It has taken a minute, but the $10.8 billion spent in 2023 — for Prometheus — is proving… wise.

Here is the latest, from FierceBio — explaining how Rahway made a largely-smart M&A move in 2023, plunking down $10.8 billion in cash, for bio-candidate developer Prometheus. [Crohns disease is another target of the former Prometheus stable of bio-tech candidates.]

…Merck has touted a win for its anti-TL1A antibody in a phase 2b trial in patients with moderate to severe hidradenitis suppurativa (HS).

The study met its primary and secondary endpoints at week 16, informing phase 3 development for tulisokibart in HS, according to the company. The win was first announced in August during its second-quarter earnings update.

“We are excited to expand the clinical data for tulisokibart beyond inflammatory bowel disease with these positive phase 2b results,” Aileen Pangan, M.D., vice president and therapeutic area head, immunology clinical research, Merck Research Laboratories, said in the release. “We look forward to advancing tulisokibart to phase 3 for patients living with HS….”

Merck inherited tulisokibart in the $10.8 billion acquisition of Prometheus Biosciences in 2023. Since then, tulisokibart has been hit-or-miss. In June, Merck reported a phase 3 victory for tulisokibart in ulcerative colitis, followed by a phase 2 fail in systemic sclerosis associated with interstitial lung disease in August….

Now you know. And we are struck by the irony, of all these wondrous life-saving advances — while overnight, Tennessee utterly fails to kill a woman adjudged very near the border for being ineligible for the death penalty due to mental infirmities.

And so, Tennessee’s taxpayers must now likely fund a woman in a permanently vegatative state, all in a very high cost hospital ICU. This obsession with retributive death — badly twice-botched, as well — is simply… beneath our supposedly-shared dignity, in a civilized society. But perhaps — just maybe — we aren’t so civilized, afterall.

[Q.: are we really that much different — than the failed Pazzi assassins hired by Pope Sixtus IV, in 1478 — or the gladiators, killing and being killed in the Colosseo, in ~220 BC? I dunno, this morning.]

Out.

नमस्ते

Now PowerLine Loves Vast Govt. Subdidies?!?

From time to time, John Hinderaker complains about the fact that there is essentially no more iron mining industry left in Minnesota.

During those times I regularly point out that the poor grade ore bodies in Minnesota are simply non-economic — in the modern world.

The miners simply cannot compete on the world stage — compared to Australia, Brazil and Canada (among a dozen others better suited to global economic realities).

Even so — tonight, Bill Glahn again complains that Iowa might get a very large steel mill operation – with some future/fantasy theory that Minnesota’s iron ore will be smelted there.

Not a chance — like everything else that Trump proposes, this is simply a silly lie. And it’s calculated to influence the midterms. But it won’t.

The only way any of that ever happens is, if Donald Trump’s federal government pays astonishingly vast monetary subsidies to both Iowa and Minnesota.

Otherwise, there is zero chance that a for-profit company will break even, after shipping these immense tonnage figures of ore by rail all the way to Iowa, for smelting. [The same stupid playbook has been used regarding coal in West Virginia by Trump.]

So I guess what we’ve learned here is that these supposed-conservatives are not conservative — at all. They favor subsidies, for their pet industries — but only in red states. Hilarious.

Here endeth the lesson.