More Good News For Merck: Sotatercept’s European Respiratory Society (ERS) International Congress 2023 Posters…

We have been following this saga, ever since Merck acquired Acceleron. This is one of the earliest potential success stories from that M&A deal. Very likely $11 billion (or more, actually) well-spent.

Here is more on the open label, post hoc data suggesting that sotatercept added to standard of care background therapies improves clinical outcomes in seriously ill cardiac patients. Merck itself put out this presser, this morning — and a bit:

…[Merck & Co.] today announced new analyses from studies of sotatercept, Merck’s novel investigational activin signaling inhibitor biologic, for adults with pulmonary arterial hypertension (PAH) (WHO Group 1) at the European Respiratory Society (ERS) International Congress 2023.

A new exploratory post-hoc analysis of right heart catheterization and echocardiography data from patients in the Phase 3 STELLAR study showed treatment with sotatercept for 24 weeks on top of background therapy reduced right heart size and improved right-ventricular (RV) function and hemodynamic status. This analysis was featured in an oral presentation, with simultaneous publication in the European Respiratory Journal. An interim analysis of the Phase 3 SOTERIA open-label extension study was also presented, representing the longest safety and efficacy analysis of sotatercept to date….

Do go read it all, as my eldest has landed in the Big Apple this morning, most recently from Reykjavík, Iceland (by way of London for most of the two months before September) — headed into the Rockies by week’s end, after a bridal party appearance. Smile. Getting pumped for it all….

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As Part Of The Latest Mars Rover Package, “MOXIE” Demonstrated Extracting Useable Oxygen, From Barsoom’s Own Atmosphere…

NASA — via Perseverance, continues to exceed expectations, on Mars.

The demonstration device called MOXIE, about the size of your old counter-top microwave, proved we could in the future — in scaled up fashion — extract enough oxygen to power booster rockets for return to Earth, from Mars itself. From its very very thin atmosphere. Excellent — but that is, of course, decades away. Here’s the Sunday night bit (and a corresponding Reuters video, at bottom):

…When the first astronauts land on Mars, they may have the descendants of a microwave-oven-size device to thank for the air they breathe and the rocket propellant that gets them home. That device, called MOXIE (Mars Oxygen In-Situ Resource Utilization Experiment), has generated oxygen for the 16th and final time aboard NASA’s Perseverance rover. After the instrument proved far more successful than its creators at the Massachusetts Institute of Technology (MIT) expected, its operations are concluding.

“MOXIE’s impressive performance shows that it is feasible to extract oxygen from Mars’ atmosphere – oxygen that could help supply breathable air or rocket propellant to future astronauts,” said NASA Deputy Administrator Pam Melroy. “Developing technologies that let us use resources on the Moon and Mars is critical to build a long-term lunar presence, create a robust lunar economy, and allow us to support an initial human exploration campaign to Mars.”

Since Perseverance landed on Mars in 2021, MOXIE has generated a total of 122 grams of oxygen — about what a small dog breathes in 10 hours. At its most efficient, MOXIE was able to produce 12 grams of oxygen an hour — twice as much as NASA’s original goals for the instrument — at 98% purity or better. On its 16th run, on Aug. 7, the instrument made 9.8 grams of oxygen. MOXIE successfully completed all of its technical requirements and was operated at a variety of conditions throughout a full Mars year, allowing the instrument’s developers to learn a great deal about the technology….

Now you know. Onward, to a short week ahead — then five days of fun, at 10,000+ feet. Be excellent to one another! Grin.

नमस्ते

Hinderaker Apparently Burped Out Some BS — On Aussie TeeVee…

Y A W N.

Really. I don’t care — do you?

Nope.

So — Hinderaker made the argument on Sky Aussie last night down under time, essentially that, since Hitler was never photographed loading Jews into the ovens… he couldn’t be charged — with the Holocaust.

Actually, he argued that the clear leader of the Proud Boys, Tarrio — who got 22 years (because he was charged with, and convicted of multiple 20-year crimes, Hinder-moron!) was done an injustice — because he wasn’t present at the Capitol on 01.06.2021.

John failed to mention… that the reason Tarrio wasn’t present
(and got 22 years!) was because he had been arrested for attacking and assaulting innocent bystanders two nights prior — and was free on bail but ordered to stay out of DC on 01.06, or face permanent jailing, to his trial date on forcible criminal assault, in the DC holding tank.

The documented evidence admitted at his insurrection trial included mountains of his own encrypted (he thought!) emails and texts… actively directing the violence that ensued. Ordering stacks of rioters to take specific steps.

So — yeah. John is, as ever… full of crap. And a regular on Sky Aussie TV Sunday night political-agit-prop shows.

Charming.

In Which Bitsy Exhorts Her MAGA GOP Buddies: “We Need To Get Better — At Committing Vote Fraud!”

Well we saw it in both the 2018 and 2020 election cycles in the red portions of Texas and Florida: it was primarily GOP factions that were caught with fraudulently “harvested” ballot forms. And not in small numbers. Tonight, Bitsy is calling for more of the same.

Fraud that is — by the GOP operatives, in electioneering.

Yet Elizabeth Stauffer is right about this much: without cheating by the GOP, the party is unlikely to win the next national presidential election cycle in 2024 — or beyond.

That is so, because the United States electorate has skewed younger, and more brown and female — in the last decades. And as a rule — each of those groups reject regressive hard right agendas. Like her MAGA agenda.

And, as more and more young people reach voting age (about seven million since 2020 cycle, come 2024)… the frothy hard right won’t be able to find enough — even with the help of fraudulent efforts — to counteract that trend, nationwide, ever again.

Cheers, Bits.

Good luck to you — and Hindrocket.

Hilarious! What’s Missing From Hinderaker’s Analysis Of Fifth Cir. Opinion? Only… Everything.

Well… That’s not terribly surprising.

John fails to mention that nine of the ten supposed harms listed, in Monroe, Louisiana Judge Doughty’s opinion (which he ostensibly “enjoined” the government from doing)… were tossed, as vague and hopelessly overbroad. Nine of ten tried to prohibit lawful activity. The Fifth Circuit tossed them.

The panel left only No. 6, which purports to enjoin government “coercion”… which is not news at all, and that limit on the fed’s powers of advocacy here — has long been well-understood and respected.

So it is mostly a hollow “win” — especially in light of the ten pages from 66 on, that I quoted from last night… excoriating Doughty’s lack of discipline, and imprecision in his opinion, and his repetition — and his… misunderstanding of well-settled law.

John mentions none of that.

But most of all, contrary to what Hinderaker wrote — there have been no findings at trial (or obviously, on appeal) of any actual governmental “violations”.

That just shows both how little Hinderaker knows about the litigation, and that Doughty’s opinion came very early in the pleadings stage — without any trial or other final factual findings.

But to hear John tell it, this was a full blown trial, and loss. Poppycock.

Now it is on to the Supremes, where the one remaining item — as to only four agencies — will be bounced on its ear, Condor predicts.

Cheers, John.

Blount Pride (Tennessee) Was Handed A Threat Letter, From A Local DA — That DA Is Now Enjoined, By The USDC Tennessee (Eastern Dist.). Tangled Web Edition…

As the “Friends of George’s” win against repression works its way through the Sixth Circuit appeal process, it has become clear that other local DAs (GOP, all) are sending threat letters (this time, out of Maryville — claiming authority to arrest and criminally prosecute drag queens — but only drag queens!) — all to intimidate the organizers of various Pride events.

On Thursday, Blount Pride won an injunction against this local DA, in the federal district courts — and now, that case will likely become part of the original one — out of Memphis, from earlier this spring/summer.

We will keep you posted, as ever.

The result in either case doesn’t even remotely seem in doubt: these purported laws violate the people’s rights under the federal First and Fourteeth Amendments.

“…This appeal calls on this Court to adjudicate whether Tennessee’s Adult Entertainment Act (“AEA”), Tenn. Code Ann. §§7-51-1401, et seq., is constitutional. Blount Pride, Inc. — a non-profit organization formed to celebrate and advance the interests of LGBTQ+ people in Blount County, Tennessee — and Matthew Lovegood, a drag performer (collectively, the “Intervenors”), seek to intervene to argue that it is not.

No other litigants are better suited to press that claim. In all of Tennessee, only the Intervenors have been specifically targeted with enforcement of the AEA’s criminal penalties, having received a threat letter from a district attorney just ten days ago for planning a Pride event that featured Matthew Lovegood’s drag performance….”

And… in a recurring bit of delicious irony, this presents a very nice opportunity — to re-run a 1977 picture of then football player / now GOP Gov. Bill Lee’s (Franklin HS) past stint as… yep, a drag queen. See at lower right. Cheers.

नमस्ते

[U] Odd: The Fifth Cir. Just Handed A Defeat To USDC Judge Doughty In Louisiana, But Dressed It In The Cloak Of A “Victory” For Hard Right Lunatics.

Some times, gifts arrive. . . wedged deep inside a huge wheel of pungent, moldy cheese.

This is one of those times. Technically, the Fifth Cir. panel sided with Judge Doughty’s view — but gutted his orders.

I confess — I did not remotely see that coming. Here it all is, and the very best part of it (starting at page 66 onward) — for those of us who still believe in democracy, and private associations’ right to exclude certain members’ views:

. . .The preliminary injunction here is both vague and broader than necessary to remedy the Plaintiffs’ injuries, as shown at this preliminary juncture. As an initial matter, it is axiomatic that an injunction is overbroad if it enjoins a defendant from engaging in legal conduct. Nine of the preliminary injunction’s ten prohibitions risk doing just that. Moreover, many of the provisions are duplicative of each other and thus unnecessary.

Prohibitions one, two, three, four, five, and seven prohibit the officials from engaging in, essentially, any action “for the purpose of urging, encouraging, pressuring, or inducing” content moderation. But “urging, encouraging, pressuring” or even “inducing” action does not violate the Constitution unless and until such conduct crosses the line into coercion or significant encouragement. Compare Walker, 576 U.S. at 208 (“[A]s a general matter, when the government speaks it is entitled to promote a program, to espouse a policy, or to take a position.”), Finley, 524 U.S. at 598 (Scalia, J., concurring in judgment) (“It is the very business of government to favor and disfavor points of view . . . .”), and Vullo, 49 F.4th at 717 (holding statements “encouraging” companies to evaluate risk of doing business with the plaintiff did not violate the Constitution where the statements did not “intimate that some form of punishment or adverse regulatory action would follow the failure to accede to the request”), with Blum, 457 U.S. at 1004, and O’Handley, 62 F.4th at 1158 (“In deciding whether the government may urge a private party to remove (or refrain from engaging in) protected speech, we have drawn a sharp distinction between attempts to convince and attempts to coerce.”). These provisions also tend to overlap with each other, barring various actions that may cross the line into coercion. There is no need to try to spell out every activity that the government could possibly engage in that may run afoul of the Plaintiffs’ First Amendment rights as long the unlawful conduct is prohibited.

The eighth, ninth, and tenth provisions likewise may be unnecessary to ensure Plaintiffs’ relief. A government actor generally does not violate the First Amendment by simply “following up with social-media companies” about content-moderation, “requesting content reports from social-media companies” concerning their content-moderation, or asking social media companies to “Be on The Lookout” for certain posts. Plaintiffs have not carried their burden to show that these activities must be enjoined to afford Plaintiffs full relief.

These provisions are vague as well. There would be no way for a federal official to know exactly when his or her actions cross the line from permissibly communicating with a social-media company to impermissibly “urging, encouraging, pressuring, or inducing” them “in any way.” See Scott, 826 F.3d at 209, 213 (“[a]n injunction should not contain broad generalities”); Islander East, 1998 WL 307564, at *4 (finding injunction against “interfering in any way” too vague). Nor does the injunction define “Be on The Lookout” or “BOLO.” That, too, renders it vague. See Louisiana v. Biden, 45 F.4th at 846 (holding injunction prohibiting the federal government from “implementing the Pause of new oil and natural gas leases on public lands or in offshore waters as set forth in [the challenged Executive Order]” was vague because the injunction did not define the term “Pause” and the parties had each proffered different yet reasonable interpretations of the Pause’s breadth). . . . We therefore VACATE prohibitions one, two, three, four, five, seven, eight, nine, and ten of the injunction. . . .

So — as I say — it is, in may ways, a gift. Looking objectively at the trial court’s injunctive order, as construed tonight by the Fifth Circuit, none of the plaintiffs can prove any violation, at any level of government, until well-after the Supremes weigh in (and they are equally likely to simply toss Doughty’s work — even as trimmed by the Fifth — as a completely incoherent bowl of spaghetti).

Only one of the ten injunctive matters survived tonight, No. Six, on “coercion” — for which there is no proof such a thing ever occurred.

So, now it is on to the Supremes, for certain. That much was never going to be a surprise. This is up to the nine. Grin. Updated: As Scott Johnson correctly points out, even the single prohibition is stayed for ten days, pending Supremes’ appeal. So, not a win in any meaningful sense. End, update.

नमस्ते

A Friday BioScience / Sea Biology Minor Mystery: What The Heck… IS THAT STUFF?!

So sorry to be an immediate, out of the gate… spoiler here… but me?

I’m betting it will turn out to be a concentrated, calcified form of… whale vomit. Also known as the “gold of the sea“. Highly prized for making very expensive perfumes, even to this day. But let’s wait and see — here’s the bit:

…The golden object was found amid white sponges and had a small hole or tear near its base that revealed a similarly-colored interior, NOAA said. Deploying a remote-controlled sub, the team was able to essentially suction the object up a tube in order to test it in a lab aboard the ship.

Testing revealed the orb to be biological in nature − but not much else….

The expedition commenced Aug. 23 off Kodiak Island conducting focused mapping and exploring depths of up to four miles with remotely operated vehicles. NOAA researchers aboard the Okeanos Explorer ship expect to conclude the expedition Sept. 16 about 350 miles north near Alaska’s southern port city of Seward….

Yep — I’m betting… whale vomit. Hah!

नमस्ते

Elizabeth… Is… Irrelevant. And She Knows It.

So, she’s bleating about someone in Oklahoma — someone who, on his own time, wears makeup and performs in satirical shows, primarily commenting on gender identity.

The weekend recreational / political work has nothing to do with the day job in charge of an elementary school.

But to hear Bitsy tell it, this is the antichrist on a stick.

Whatever, Bits.

Evidence of anything untoward? Of course not.

Just more of her blind ugly hate… of anyone who is not a carbon copy of her, and her repressive choices.

Whatever. You and your view… is not to be taken seriously — and you are… increasingly… irrelevant — in 2023.

Cheers.

“DO Look Up!” — This Weekend — To Catch A Pre-Dawn View Of The Comet Nishimura. It Won’t Return Until The Year 2435…

In the last hour or two, before sunrise this weekend — into Tuesday, if you look toward the northeastern horizon, low in the sky — near Venus at that time of night… you will seek the long hook of the constellation Leo, or the Lion. [I think Venus will be appear to be setting, as Leo is rising, then. See my illustration at right, derived from the wonderful and free Distant Suns iPhone app.]

Here are all the other sky-watching details you’ll want to know, from LifeHacker online:

…The universe is delivering a cosmic gift this coming week — a newly discovered comet will zip by earth to say hey before leaving our planetary neighborhood for more than 400 years. The green comet C/2023 P1, or “Nishimura,” is already visible in the predawn sky, but over the weekend it will grow brighter and should be visible without a telescope or even binoculars….

On Sept. 10, it will rise at 5 a.m. It will appear closer to sunrise each subsequent morning, until Sept. 17, when it will be invisible because of the glare of the sun. Tuesday, Sept. 12 is the sweet spot: That’s the night Nishimura will be closest to the earth — only 78 million miles from your house….

Excellent (that is well inside the Earth’s orbit distance — from the Sun). As you know, interstellar celestial events… always fire my imagination. It was essentially… ever thus (away from light pollution in the high Rockies of my youth, the night sky is literally powdered with wonders). Smile.

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