In Which “Rigby” Runs Circles Around… Hinderaker.

Hinderaker’s — of tonight — evoked some inspired realism, from Rigby (I am proud to call him a regular commenter).

Here is Rigby’s — and it is ALL spot-on:

…I love the never-ending complaint, “The Democrats keep running on the abortion issue!” Well, yeah.

It’s an issue about which the vast majority of the country disagrees with you (and fellow Republicans). Why wouldn’t they run on that issue? In an election after election, it’s a winning issue for Democrats and a losing issue for Republicans. In a normal society, this would cause Republicans to self-reflect and adjust their stance to be more in line with the voting majority. But no. They just double down and complain that Democrats are extolling their own strengths and exploiting the Republicans’ weakness — as if this were a dastardly trick rather than a winning election strategy.

Also, Hinderaker’s lament that Republicans should run on the economy may be grounded in a small kernel of truth (public misperception), but it’s not grounded anywhere near reality, as the economy is just humming along under Biden. Inflation is decreasing, unemployment is down, and the numbers are generally rocking. Similarly the Republicans’ so-called “strength” on border issues is also grounded in misperception, in that the Biden administration is adhering to existing law. There is a bipartisan immigration reform bill in Congress, but Republicans won’t vote for it because they don’t want to give Biden a win.

If I have any frustration with Democrats’ messaging, it’s not their focus on abortion (which, again, is a winning issue for them), but rather their failure to punch back against the two glaringly obvious public misperceptions I outlined above….

Excellent!

And now you know….

Hinderaker “Has A Sad” About The ‘24 Issues He’s Created

So… very few people have written more pieces (and certainly no one has, with less grace!), to ensure that hatred (in its many forms) might become the only common plank, among all the fractured Republicans… than John.

So it’s a little precious to hear his lament — just now — that abortion will not be an issue the GOP can blunt, with distractions, like the southern border.

But under all his endless burpings, of course, is the implied but clear admission: GOP is dead stick in ‘24 under Tangerine.

And… I love that.

He’s your monkey, John — this is the circus you bargained for.

Cheers.

[U] 5-4 — Supremes Hold That Mr. Biden May End TX GOP Gov. Greg Abbott’s Cruel And Lawless Use Of Razor Wire Barriers, Against Asylum Seekers. Excellent.

Well. . . .

It took almost six months, but that’s effectively game over — for this particularly heinous part of Texas’s “Operation Lone Star“. States do not have the right to usurp federal control of border matters. Period. Here was my “hot take” comment on it. [Update — and to make my hot take accurate, replace Barrett with Gorsuch, throughout, below. W I L D.] Woot!

…I’d say… “winning ugly is STILL… winning!”

It means Chief Justice Roberts voted that razor wires by Texas violate our treaties and the US immigration laws.

Not sure who might have been the fifth vote, but the Chief is certainly among the five.

And while some people still believe each Justice decides these matters utterly… independently (in some ivory tower — that is not remotely the reality… these folks more than occasionally eat lunch together; go to the theater, or opera, together and function like any other social group), so I’m gonna’ bet that once Gorsuch Barrett saw Roberts was moving to dissolve the injunction (previously in favor of Texas)… she likely didn’t want to be on the wrong side of history.

So… the holdouts were most likely Thomas (of course!), Alito, Kavanaugh and Gorsuch Barrett.

Namaste….

Now you know. With A H/T to Anon.!

नमस्ते

Power Alley: Gilead NYSE Price Declining ~10%, After A Miss In NSCLC For Trodelvy®… 3 EVOKE-1 Trial — Bad News For Lung Cancer Patients.

This is one very large, fragile and complex molecule — so big, in fact, that PubChem’s software cannot offer a 3D version, as it bends too much. [Just look at the small-scale flat long chain strand in red and blue at right (the only way to fit it on the screen is… “tiny”); that’s a big honking molecule!]

Thus, while it is technically in the antibody-drug conjugate (ADC) classes, no one should draw any inference about ADCs, more generally — there are (by far!) just way too many moving parts, here.

And so, Merck’s efforts (and big ticket spending) on ADCs will move forward, and will likely see other successes — and even Gilead’s sacituzumab govitecan (the chemical name for Trodelvy®) is doing well, in certain breast cancers, and is running other trials in head and neck cancers.

Here’s a fine analysis — as ever — from FiercePharma, and a bit of it:

…The company’s phase 3 EVOKE-1 trial showed that Trodelvy didn’t significantly extend the lives of patients with previously treated metastatic non-small cell lung cancer (NSCLC) when pitted against the chemotherapy docetaxel. With that, the trial failed to meet its primary endpoint, Gilead said Monday.

Despite the fail, the “totality of our data” gives the company “continued confidence” in Trodelvy’s potential in the population, chief medical officer Merdad Parsey, M.D., Ph.D. said in the company’s press release….

…[T]he NSCLC miss could spell trouble for Trodelvy. As it stands, the ADC’s breast cancer market share is limited to previously treated HR-positive, HER2-negative as well as triple-negative breast cancer. But Daiichi Sankyo and AstraZeneca’s rival HER2-directed ADC Enhertu and its groundbreaking approval in new breast cancer category HER2-low puts pressure on Gilead’s offering….

Onward, smiling — but Merck’s Daiichi Sankyo ADC deal looks… pretty smart here (again!). Grin.

नमस्ते

Of Issues Beyond Hinderaker’s Now Impaired Abilities…

His column tonight is yet another example of this phenomenon.

He has lost the discernment… the ability to see subtlety — in any event.

He cannot accept that many women may not want to be thought of as the “problem”… in falling birth rate discussions.

And some portion of all women may resent being told they have a “duty” to bear offspring.

So Hinderaker goes off — rather wildly — about women… having opinions he doesn’t share.

Obviously, John thinks it his place to tell them what they are “allowed” to think.

Nutty. This seems a cognitive issue, on Hinderaker’s end.

Out.

[U] Yes, Trump WILL LOSE. And So… Where’s Your “Serious President”, Now John?!

Hinderaker trafficks in the obvious today… as DeSantis exits, in a whimper.

Y A W N. John complains about the man he helped to create — to push forward, and defend… in most cases, in indefensible terms.

Damn.

Here’s Hinderaker, just now:

…Trump has many flaws. He is a poor manager. He is not, in some ways, a conservative; in particular, he seems oblivious to the fiscal catastrophe toward… which [he accelerated the nation toward, for four years — with graft and corruption on every contractual corner]. He is inarticulate, and therefore incapable of moving Americans in the middle toward his (usually, our) positions. And if he wins, he will be 78 years old when he is inaugurated….

Of course, we all know… he cannot win. But the point remains: Hinderaker loved this malign idiot, when the grift was benefitting his little think tank.

Updated: late Sunday night, Mirengoff burped up a post that adds little to Hinderaker’s — on DeSantis’ exit. But he is even more certain than John that the GOP cannot win in 2024, as a result. Hilarious. Finally! End update.

Now — when it is clear Trump not only cannot grift for him – but may be a convicted felon by November, awaiting a prison bid?!?

Not so much… Hinderaker cuts bait, and runs.

Yep, Hinderaker (and others, like Mirengof, Johnson and Hayward) chose to break the GOP brand… to subvert it… to banal criminality… just to line their pockets.

Disgusting.

What Subverting The Justice System Looks Like: Trump In Sex-Assault Libel Case…

Let’s cover a bit of the second Carroll case. She is likely to win five times the damages in this second trial as she won in the first one — that was $5 million. Then Tangerine doubled down on his lying attacks on her — related to his sexual assault of her.

So now he faces far larger boxcar numbers, before the jury. With closings set for Tuesday, let’s look at Tangerine’s conduct: as ever, he tries to tar his accuser rather than admit a jury has already determined he committed the sexual assault, and then lied about it in public to harm Ms. Carroll. Do read all five pages:

…[Trump] has made repeated comments about trial evidence within earshot of the jury… he has sought to develop the public narrative that the Court is not “allowing [Trump] to properly defend [himself] from false accusations”…. He has stated on the record that he “would love” if Your Honor excluded him from the trial for disregarding court orders or engaging in disruptive behavior….” [And, from a later filing:]

…Here, Mr. Trump has been held liable for defamation under the actual malice standard. It would thus be profoundly inequitable to allow him (through his defamatory attacks) to “force a benefit on [Ms. Carroll] against [her] will.” See id. Given the utter absence of good faith and reasonableness in Mr. Trump’s conduct — and given that his conduct was malicious and intentional rather than negligent or mistaken — Mr. Trump cannot equitably avail himself of the benefits rule, event to the extent that rule applies under New York law in this setting (which it does not)….

Because Mr. Trump’s opening argument and cross-examinations plainly indicated to the jury that Ms. Carroll’s damages should be reduced by the amount of any reputational benefit she received from his defamatory statements, and because that contention rests on a mistaken legal premise, Ms. Carroll respectfully requests that the Court’s jury instructions address this issue. For example, the Court might include the following language in its instructions on defamation damages: “Under the law, the injury (if any) that Mr. Trump caused to Ms. Carroll’s reputation by his defamatory statements is not mitigated by any benefit to her reputation that Mr. Trump may claim that his defamatory statements caused in some parts of the community. You are not to consider any such reputational benefits (if any) in deciding on a damages award in this case.”

In addition, Ms. Carroll would also request that the Court issue an order precluding the defense from making any argument to the jury in summation that is inconsistent with this legal rule. reputational benefit to Ms. Carroll—and, if so, whether he can offset damages on that basis. The answer to that question is clear. As a matter of precedent and equity, the law does not authorize Mr. Trump to defame Ms. Carroll but then minimize the ensuing damages because he involuntarily inflicted a “benefit” on her in the form of support from parts of the community who find his statements abhorrent (or who are otherwise predisposed to disbelieve his attacks).

Ms. Carroll never asked for any “benefit” that Mr. Trump may think that he has forced upon her through his defamatory attacks. If anything, it is offensive for him to persist in his assertions that she should be grateful to him for defaming her. And it is equally absurd to claim that her damages are less substantial just because his unlawful, unwanted, and unwelcome attacks on her reputation provoked sympathy in some parts of the public or drew more attention to Ms. Carroll. If Ms. Carroll suffered harm to her reputation — which she plainly did — then she deserves to be fully compensated for that injury. If she somehow benefited in any respect from the President of the United States falsely calling her a liar and a fraud (and threatening and insulting her), the law of New York does not reward Mr. Trump for that collateral result of his own tortious malfeasance.

Because Mr. Trump’s opening argument and cross-examinations plainly indicated to the jury that Ms. Carroll’s damages should be reduced by the amount of any reputational benefit she received from his defamatory statements, and because that contention rests on a mistaken legal premise, Ms. Carroll respectfully requests that the Court’s jury instructions address this issue. For example, the Court might include the following language in its instructions on defamation damages: “Under the law, the injury (if any) that Mr. Trump caused to Ms. Carroll’s reputation by his defamatory statements is not mitigated by any benefit to her reputation that Mr. Trump may claim that his defamatory statements caused in some parts of the community. You are not to consider any such reputational benefits (if any) in deciding on a damages award in this case.” In addition, Ms. Carroll would also request that the Court issue an order precluding the defense from making any argument to the jury in summation that is inconsistent with this legal rule….

Mr. Trump’s claim that his defamatory statements were somehow a form of self-defense, whether he intends that in a political or personal sense, it is meaningless as a legal matter: when a person commits sexual assault and their victim reveals what they did, the law confers no right of self-defense to make defamatory statements aimed at crushing or humiliating the accuser. Giuffre v. Dershowitz, 410 F. Supp. 3d 564, 576 (S.D.N.Y. 2019) (explaining under New York law that a finding of constitutional actual malice defeats any self-defense privilege in defamation cases)….

Now you know.

Onward to a Trump loss — here, in Manhattan in a few days… and, in November 2024.

Trivia: Scott Continues To Offer… Irrelevant And Libelous Lies, In Service Of MAGA/Tangerine In Georgia…

This is truly… of no moment — but I want to note it for the record, and the Powerliners’ continuing willingness to serve the Orange Dotard — even where, as lawyers — they KNOW this BS is both irrelevant and libelous. So my Sunday morning trivial update follows. [Our original coverage may be found, here.]

Updated: January 21, 2024 — It is now clear (from Scott’s own linked updates) that the ex- of the junior prosecutor is simply angling for more money, in a no-fault divorce. And in any event, there is zero inference (even if what she alleges was true) that this in any manner affected the prosecution of any MAGAt, or Tangerine himself, for election fraud, in Georgia.

It is simply churlish, and truly sensational nonsense — to try to embarrass a prosecutor. And Ms. Willis has now labeled the ex-‘s attempt as “attempted obstruction” of a criminal proceeding. Ms. Willis is correct — and the ex- could easily be charged criminally before long, if she persists in this graymail. End updated portion.

The Georgia Bureau of Investigations has issued a press release earlier this week, to the effect that there is “nothing to investigate“. [These are, as a rule, GOP-leaning law enforcement officers in Georgia, btw.]

So… there is no… there, there.

Out.

The European Space Agency’s Efforts Continue To Refine Our Understanding Of Where Ice Deposits Might Lie, On Mars…

The water ice is under many hundreds of feet of blown dust — frigid dunes, near the equator… so using it for any crewed exploration presents a daunting recovery and conversion challenge — from a chemistry / engineering perspective… but the water is… there, in abundance, still.

ExoMars has refined the measurements of it, and in spots the ice is kilometers thick… plenty to sustain humans, if we can extract it, in situ. Here’s that story — and a bit, from our partners in Paris:

“…This latest analysis challenges our understanding of the Medusae Fossae Formation, and raises as many questions as answers,” says Colin Wilson, ESA project scientist for Mars Express and the ESA ExoMars Trace Gas Orbiter (TGO). “How long ago did these ice deposits form, and what was Mars like at that time? If confirmed to be water ice, these massive deposits would change our understanding of Mars climate history. Any reservoir of ancient water would be a fascinating target for human or robotic exploration.”

The extent and location of these icy MFF deposits would also make them potentially very valuable for our future exploration of Mars. Missions to Mars will need to land near the planet’s equator, far from the ice-rich polar caps or high-latitude glaciers. And they’ll need water as a resource – so finding ice in this region is almost a necessity for human missions to the planet….

Now you know. Another round of snow and sharply colder sub-zero weather ahead tonight, but then warming into a tropics like 40 degrees, by Monday afternoon. Woot — almost like being on… Barsoom (well, not really). Heh.

नमस्ते