I Wonder Whether Hinderaker Can Name Even One Thing The GOP Is “For” — And “Did” Since 2021.

Tonight, he goes back into his tedious old jag about how bad (i.e., liberal) Minnesota state government is.

Then he preposterously labels Florida, Texas and Tennessee as “pro-freedom” states. And claims they are all doing better than Minnesota or Illinois or Colorado or NY (may have a marginal point — as to NY).

But as we’ve long proved… Florida, Tennessee and Texas are all only pro freedom — if the “freedom” is the nearly unlimited ability to impose fundamental X-tianity on the populace; to limit women’s rights to body autonomy… and allow large businesses to rip off consumers without a second thought.

In sum, they are becoming failed dictatorships — and in the case of Texas, lawless vigilante states — abusing putative asylees — by the tens of thousands.

Oh, and they all take more from federal coffers than they put in, in tax revenues.

They are… largely welfare states — taking federal largesse, while complaining that the feds are oppressing them. Damn John.

Just… damn.

I do want to note almost in passing — that John never offers positive new ideas, claimed conservative ideas… to address any (largely pretended) ill he purports to see. These dead enders are exclusively the party of no; of division; and of hate… now.

Out.

Flores Plaintiffs Win Order Directing Immediate Clean Up Of Open Air Detention Sites; Removal Of Children From Same.

This has been widely expected.

The able USDC Judge Dolly Gee has again ruled that putative asylees being held in squalid open air containment sites south of San Diego — but this order applies to any open air site in Texas, Arizona and/or California. Each person detained by CBP — whether an adult or child — must be provided with guaranteed rights and essentials from the original Flores consent order of 1985. This the US CBP (and DHS and HHS) must do… right now. Tonight.

In sum, basic hygiene, and sleeping materials must be provided — soap, water, toothpaste and brushes — as well as at least bedrolls / sleeping bags.

It is frankly deplorable that any US governmental agent would oppose complying with our laws and treaties… but there are a few active resisters in the CBP ranks.

This ends all of that — again. Just as USDC Judge Gee did, under Tangerine… about five to six years ago.

Now you know.

Mirengoff Wryly Notes: “Slimmest of Chances, Here…” Me? He’s More Likely To Have A House (From Kansas!) Fall On Him.

Well, this is a pretty sane take from Paul.

The seven [MAGAts in the US House] are Guy Reschenthaler (R-PA), Andrew Ogles and Chuck Fleischmann (R-TN), Michael Waltz (R-FL), Paul Gosar (R-AZ), Barry Moore (R-AL), and Troy Nehls (R-TX)…. In America, we don’t name major facilities like airports after active politicians, much less presidential candidates. That’s banana republic stuff, and we haven’t attained that status quite yet….”

— And… that’s Paul speaking, immediately above, BTW.

They want Dulles renamed… Tangerine Airport?! Hilariously… demented.

Honestly, doesn’t the GOP have better things to spend time — tilting at windmills for?

Geez.

Look out, Cheetolini. Houses do fall, from the sky. And it is looking to be a fairly severe hurricane and tornado season, in the US now — as he criss-crosses the heartland in search of votes. Wow.

You’ve been warned. Heh.

Out.

[U: Seton Hall Wins NIT!] Still Immaterial — For Now — But Merck’s MK-1084 Candidate Begins Combo Trials, In Certain Lung Cancers… Goal Is To Enroll 600 Patients.

This will be a study of the ivestigational agent MK-1084, in combination with Keytruda® (pembrolizumab) — in patients not previously treated, but whose lung cancer expresses certain promising PD-L1 levels.

We will follow up, when results are released, in a peer reviewed process, or journal article. Good news for Rahway — and… without further ado, here’s the latest bit:

…The trial, which began enrollment on Monday, will assess the combination therapy’s impact on progression-free survival and overall survival in approximately 600 patients worldwide. These patients have not received prior treatment and have tumors harboring KRAS G12C mutations with PD-L1 expression levels of 50% or higher.

Merck’s decision to proceed with a larger Phase 3 trial follows promising early results from a Phase 1 study, indicating that the MK-1084 and KEYTRUDA combination had a manageable safety profile and showed potential in tumor reduction. Dr. Marjorie Green, senior vice president and head of oncology global clinical development at Merck Research Laboratories, emphasized the significance of targeting KRAS G12C mutations, which are prevalent in NSCLC cases.

Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite advances in early detection, screening, and new therapies, the five-year survival rate in the United States is only 25%. Merck’s latest trial is part of its ongoing commitment to improving outcomes for lung cancer patients through extensive research and clinical trials….

Obviously, if these trials prove out — the combo package becomes a very legit way to extend the life of Keytruda’s exclusivity in the oncology markets, world-wide — for those (relatively few, in terms of the globe’s annual income levels per patient) that are able to afford the therapy.

Now you know. Onward, grinning — no snow, just rain now — and I’ve got Seton Hall in the NIT final tonight.

नमस्ते

Enid, Oklahoma Sends A Whyte Separatist Council-man… Packing.

And again — i’ll run no image of him — he should just… disappear — into obscurity now. [Again Hinderaker equivocated about Charlottesville with “whataboutisms”.]

But voters have recalled him, after he was shown in Charlottesville with a Tiki-Torch as a “unite the Whyte right” boy, and had subsequently led Whyte nationalists in Oklahoma.

Read on, it is… not at all surprising that he says this is what Tangerine wanted, from him:

Voters in Enid, Oklahoma, have decisively kicked out a city council member with a history of ties to white nationalist groups from the elected body almost a year after he was admitted.

Judd Blevins lost his position as Enid’s ward 1 council member, according to Oklahoma’s state election board. The move comes months after Blevin was shown to have attended a deadly neo-Nazi rally in Charlottesville, Virginia, in 2017 and was later shown to have led an Oklahoma chapter of the white nationalist group Identity Evropa.

Blevins denied he was or ever had been a white supremacist, and said he was motivated by “the same issues that got Donald Trump elected in 2016”.

A small group of 36 Blevins supporters had won him election last year, but he lost Tuesday’s vote to fellow Republican candidate Cheryl Patterson who had campaigned on a platform of returning Enid to “normalcy” and appears to have defeated Blevins by a 20-point margin, or 268 votes….

Very fine people, indeed — insane.

D A M N.

J6 “Megaphone Leader / Cop Assaulter” Guy Gets More Than 7 Years…

I won’t glorify this loon’s name. You may read it, at the AP’s link. He espouses much of the so-called “sovereign citizen” BS.

What matters here is that he assaulted police officers, led the charge to push through the barricades, and barked commands to the crowd — via his megaphone.

He also said over his megaphone that since Mike Pence was moving to certify the election results, “we are left with the nuclear option only!

He then shouted “Let’s Go!” and charged the Capitol officers.

Yep. He’s been right where he belongs for the last two years (jailed awaiting disposition), and my understanding is that he will not get credit for the time served while awaiting sentencing — as he’s expressed the opposite of remorse, and continued to harangue USDC Judge Lambreth loudly — peppering him with questions — as he was being sentenced.

No convict gets any right to cross-examine their sentencing judge, once convicted. And this judge was having none of it. [Just ask Stewart Rhodes, disbarred lawyer at right.]

The USDC Judge told the megaphone guy “I’m not here today to answer any of your questions. You are being sentenced.”

All in, that looks like closer to nine years — but still about half as much time as the Oath Keeper preposterous looking-baddie is serving — at 18-plus years.

But let’s be clear — these are the same guys Hinderaker praised as “tourists” — and defended — saying they were within their rights to assault the police (once officer died in the melee, as did Ashli Babbitt).

[Paul had an only slightly more… rational view of it all.] Damn, John.

Onward.

Serious Scientific Q.: What Was Going On In Patient One’s Brain — As She “Died”?

The Guardian (UK) has a very provocative life-science tale this morning. Or, perhaps — more precisely… a death-science piece.

What will be required for a better understanding of the physiological phenomenon is… more people (with terminal conditions) signing informed consents to allow invasive — and comprehensive — monitoring of their brain-wave functions, as they approach and pass into… what we think of as clinical death. Do go read it all — and come to your own conclusions:

…In the moments after Patient One was taken off oxygen, there was a surge of activity in her dying brain. Areas that had been nearly silent while she was on life support suddenly thrummed with high-frequency electrical signals called gamma waves. In particular, the parts of the brain that scientists consider a “hot zone” for consciousness became dramatically alive. In one section, the signals remained detectable for more than six minutes. In another, they were 11 to 12 times higher than they had been before Patient One’s ventilator was removed.

“As she died, Patient One’s brain was functioning in a kind of hyperdrive,” Borjigin told me. For about two minutes after her oxygen was cut off, there was an intense synchronisation of her brain waves, a state associated with many cognitive functions, including heightened attention and memory. The synchronisation dampened for about 18 seconds, then intensified again for more than four minutes. It faded for a minute, then came back for a third time.

In those same periods of dying, different parts of Patient One’s brain were suddenly in close communication with each other. The most intense connections started immediately after her oxygen stopped, and lasted for nearly four minutes. There was another burst of connectivity more than five minutes and 20 seconds after she was taken off life support. In particular, areas of her brain associated with processing conscious experience – areas that are active when we move through the waking world, and when we have vivid dreams – were communicating with those involved in memory formation. So were parts of the brain associated with empathy. Even as she slipped irrevocably deeper into death, something that looked astonishingly like life was taking place over several minutes in Patient One’s brain….

Fascinating. She did not survive, so we will never have her report of what she was experiencing. But provocatively… intriguing just the same. Patient One was a few weeks pregnant at the time of death, so could it be that it was an accounting of two lives rather than one? We will never know — but fascinating, indeed.

Equally obviously, if hundreds (or thousands) of patients were to sign such consents… it will be very likely that at least some few, will pass into “clinical death”, and then return for a bit, from it — hopefully able to report on what it was they’d experienced, when/if their brains went into an objectively observable “hyper-drive” mode.

नमस्ते

A Swedish BioScience Company Will Run A Phase I/IIa Study Of Its Monoclonal Antibody, In Conjunction With Merck’s Pembrolizumab…

Clearly miniscule in size, as to the behemoth that is Rahway, overall — and it is being conducted through Merck’s EU business development subsidiary — but this is a nice piece of bio-business validation, for smallish BioInvent.

The company is located near the southern seaward tip of Sweden, in Lund — and could see its financial future mightily enhanced if the combo trials go well, and it meets the ultimate primary endpoints, of overall survival — in various solid tumor cancers.

Here’s the bit, from The PharmaLetter:

…Swedish immuno-oncology specialist BioInvent International announced a clinical trial collaboration and supply agreement with MSD International Business GmbH, a subsidiary of Merck & Co. for a Phase I/IIa study of its monoclonal antibody BI-1910 in combination with the US pharma giant’s blockbuster cancer drug Keytruda (pembrolizumab)….

Now you know. Onward… and grinning, in spite of the lazily wheeling snowflakes, this morning. They aren’t sticking. Yet.

नमस्ते

[U: UK Reporting Russian-Tied Investigations] As The Audit Firm Expresses Substantial Doubt About Its Survival, DJT Sues His OWN Founders, In Florida Court. Heh.

This is just so… “on brand” — for these jokers.

A new audit firm just amended the SEC Form 10-K, to say there is substantial doubt about the company surviving as a going concern. And Tangerine himself sues his original founding group, alleging they mismanaged the structuring, and set up. The more likely reality is that this is simply a dumb business model. If Musk’s X-itter cannot make a profit with about five thousand times the audience draw — it may well be that there is no set of ads, that will ever let DJT break even.

Hilarious — here’s the latest:

…Donald Trump has sued two co-founders of his newly public Trump Media & Technology Group Corp., claiming they set the company up improperly and shouldn’t get any stock in it.

In the latest legal skirmish over who gets how much of the hot but flailing meme stock, Trump alleges that Andy Litinsky and Wes Moss violated an agreement about the setup and don’t deserve their 8.6% stake, currently valued at $606 million.

The lawsuit, which was filed on March 24 in Florida state court and hasn’t previously been reported, comes after the pair brought their own suit against the former president in Delaware Chancery Court over their promised stake in the social media company….

[Amended SEC Form 10-K:] Substantial Doubt about the Company’s Ability to Continue as a Going Concern

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, it is uncertain that the Company will consummate a business merger in the allotted time. If a business merger is not consummate [sic] but [sic] the specified date, there will be a mandatory liquidation and subsequent dissolution of the Company. Additionally, the Company has incurred and expects to incur significant cost in pursuit of its acquisition plans. These factors raise a substantial doubt about its ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of this uncertainty….

UPDATED — Overnight, the UK Guardian reports as follows:

Through leaked documents, the Guardian has learned that ES Family Trust operated like a shell company for a Russian-American businessman named Anton Postolnikov, who co-owns Paxum Bank and has been a subject of a years-long joint federal criminal investigation by the FBI and the Department of Homeland Security (DHS) into the Trump Media merger.

The existence of the trust was first reported by the Guardian last year. However, who controlled the account, how the trust was connected to Paxum Bank, and how the money had been funneled through the trust to Trump Media was unknown….

What a… clown show. This is a $2/share stock, fairly valued. Nothing remotely close to $50.

नमस्ते

Aimee Harris: Congrats! Due To Your Own Flagrant Repeated Lyin’ — In Federal Court, You ARE Going To… Jail!

Tonight the able AUSAs have weighed in, with revised suggestions, for USDC Judge Swain, in Manhattan, on Aimee Harris’s sentence.

They are revised, because for now more than a dozen times, she has failed to abide by federal criminal court orders. Including at least five failures to appear.

Now April 9 will presumably be the end of the line — and these six pages set out how little respect she’s shown for the weight of the federal plea she entered almost two years ago.

Here’s the upshot: the new recommendation includes real incarceration, for 4 to 10 months — followed by three years of close supervision, thus:

At bottom, the defendant’s flagrant disrespect for the law, including the orders of this Court — even after pleading guilty in this case — demonstrates an abdication of responsibility for her conduct and strongly militates for an incarceratory sentence. In particular, the defendant has shown to be completely unamenable to court supervision such that a sentence involving merely probation will not be sufficient to deter the defendant from continuing to flout the law.

Moreover, a sentence involving no period of incarceration would be wholly insufficient to reflect the gravity of the defendant’s conduct, including her apparent belief that she is above the law and that she need not comply with this Court’s orders. A Guidelines sentence involving a period of incarceration, by contrast, would send the message that breaking the law and then failing to abide with the orders of the Court during the pendency of a criminal case will not be tolerated and will have serious consequences. For all these reasons, the Court should impose a sentence within the applicable Guidelines range….

For the reasons set forth above, the Court should impose a sentence of 4 to 10 months’ imprisonment, to be followed by three years of supervised release….

Here’s to hoping Judge Swain shows Harris… who’s boss, on the 9th.

Prison is absolutely appropriate here.

Onward.