No, Paul — But It Is… HILARIOUS, That Tangerine Calls ANYONE “Stupid”. Et tu, Brutus?!

Overnight, Mirengoff wastes about ten paragraphs, burping nonsense, to supposedly defend the Tangerine moron’s right to call his opponents “stupid“.

Y A W N.

Sure, he has that right — and “stupid” by itself (in a debate in an academic vacuum) may not be racist, or sexist. But Paul entirely neglects to mention Tangerine’s… “context“. In front of the NABJ in Chicago, he spoke for five minutes about how he “can’t tell” if she is Black or Asian Indian.

He has called her “Cacklin’ Kamala” (a witch), and “re-truthed” memes on his platform that mis-spell her name, in order to refer to her… by her genitals.

He’s sent out riffs on who (he falsely claims) she was a Jezebel with.

So, yeh — Paul, that one word adjective, standing alone — may not be racist. But all his others, in context, make it clear that for him, this is a dog-whistle to [purported] Whyte supremacists… that she’s a mud person, and a loose-womyn, to boot.

Most of all, though, I write to laugh that Paul thinks Tangerine is not — by a wide margin — the dumbest preznit we’ve ever seen. He can barely read — and he thought that Mississippi was Alabama on a map he used to explain… hurricanes.

Damn, Paul. He thinks the fictional cannibal Hanibal Lector is… his “good friend”.

You should sit this one out.

Having Previously Won US Approvals, Pembrolizumab Has Now Cleared The EU, For Two Kinds Of Advanced Gynecological Cancers… [Immaterial News]

This is good news, but quite a few patients were already enrolled in the studies that won the earlier FDA approvals, so it will mean only marginal growth in revenue, for Merck — but still very good stuff.

Most of all for women whose gynecological cancers have progressed, this offers some hope. Here is the Merck press release:

…[T]he European Commission has approved two new indications for KEYTRUDA® (pembrolizumab), Merck’s anti-PD-1 therapy, in gynecologic cancers. The first approval is for KEYTRUDA, in combination with carboplatin and paclitaxel, for the first-line treatment of primary advanced or recurrent endometrial carcinoma in adults who are candidates for systemic therapy. The second approval is for KEYTRUDA, in combination with chemoradiotherapy (CRT), for the treatment of FIGO (International Federation of Gynecology and Obstetrics) 2014 Stage III-IVA locally advanced cervical cancer in adults who have not received prior definitive therapy. With these decisions, KEYTRUDA is now approved for 30 indications in the EU, including five in gynecologic cancers – three in endometrial cancer and two in cervical cancer.

“These KEYTRUDA-based regimens have the potential to change the treatment paradigm for people with endometrial and cervical cancer, two of the most commonly diagnosed cancers among women in Europe,” said Dr. Gursel Aktan, vice president, global clinical development, Merck Research Laboratories. “These approvals underscore the continued expansion of the use of KEYTRUDA in diverse patient populations and treatment settings with utility of KEYTRUDA ranging from earlier lines of therapy to treating advanced disease….”

In January 2024, KEYTRUDA in combination with CRT was approved in the U.S. for the treatment of patients with FIGO 2014 Stage III-IVA cervical cancer based on PFS results from the KEYNOTE-A18 trial. The KEYTRUDA regimen reduced the risk of disease progression or death by 41% (HR=0.59 [95% CI, 0.43-0.82]) versus concurrent CRT alone for these patients….

Both of these populations for treatment cleared the US FDA earlier in the year. Now you know. Onward, smiling — voting early, tomorrow. Go Buffs!

नमस्ते

Hinderaker: Sans… Human Bioscience. And… Humanity. Again

Hinderaker thinks it is “thousands”?!

In the State of Florida… it was five people, in a decade.

That’s in ten years. And…

Even fewer — in Texas, Tennessee and Missouri.

So… John’s a lying ass. Gender dysphoria is a real but rare medical condition. John and his fellow Brown-shirters, though, want to dictate what doctors can and cannot do — in consultation (in privacy) — with their patients. And their parents.

How unsurprising.

Again.

Out.

Well… this is just… precious! McD’s, Seriously [Again!] Scott?!

Between Musk’s felonies, and the Powerline boys… obsession with a summer fry-cook job at McD’s, some 45 to fifty years ago… we just have to laugh.

This is what desperation looks like folks.

Buying voter registration lists, via a million dollar a day raffle, and… writing about her summer jobs, as a high schooler. My recollection is that Tangerine was — in his high school years — sent off to a reform/military academy, by Fred Trump… because he refused to act like a human being.

He never held a wage paying job in his life. He has no idea what groceries cost — nor what gas costs.

In sum, he has never lived paycheck to paycheck… like almost all Americans have, at one time or another. Never held a job where he had to serve any [even unreasonable] customer, on pain of losing his meager paycheck.

But this is what Johnson, Musk, and / or… Trump (preposterously) think will put him/them over the top, with undecideds?

Cool story, bros… cool story.

H I L A R I O U S!

Out.

Roche To Greatly Increase Output Of Mpox PCR [Diagnostic] Test Kits, For Africa, And EU…

At the opening of this month, we mentioned that Abbott had cleared FDA emergency authorizations to deliver its kit into Africa, to track the spread of Mpox. Now Barron’s reports that Roche will also ramp up production of its own Mpox PCR test kits.

This is good news, but with over 42,000 cases — it needs to be done, like yesterday.

. . .Swiss pharmaceutical giant Roche said Wednesday that it was increasing its capacity to produce diagnostic tests to detect mpox, amid a flare-up of the potentially deadly virus.

“We’ve ramped up our production in order to meet potential demand,” Roche chief Thomas Schinecker told reporters as he presented the company’s third quarter sales results.

Fresh outbreaks of the viral disease — some involving a new variant — have hit a range of countries in Africa in recent months, with more than 1,100 mpox deaths recorded on the continent so far this year, according to the African Union’s health agency.

The disease has also spread further afield, with Germany on Tuesday recording a first infection with the new mpox variant clade 1b, while single cases have also been detected in Sweden and Thailand.

“It seems like there are more cases in Europe,” Schinecker said.

“Maybe they are not all in the media yet, but there are already more mpox cases.”

Roche first developed its PCR test to detect mpox during the 2022 outbreak.

Schinecker, who previously headed Roche’s diagnostics unit, did not disclose Wednesday how many tests the company was currently making.

“But we could manage probably a 10-times higher demand,” he insisted.

Roche, the world’s largest maker of cancer drugs and one of the biggest makers of diagnostic tests, on Wednesday posted better-than-expected sales for the first nine months of the year, up two percent at nearly 45 billion Swiss francs ($52 billion)….

Now you know — onward, resolutely… onward.

नमस्ते

Only $30 Million At Close, But Could Be $1.3 Billion, If Glioblastoma (GBM | MOD-246) Asset Clears FDA — Still Immaterial To Merck: Modifi Bio Acquisition

This is a very rare type of cancer overall, but a fairly common type of brain cancer — and a very daunting one, as it seems patients lack the ability to repair their DNA after an attack, unlike most other cancer survivors on the chemo agent temozolomide.

The allure for Merck is the Yale University Med pedigree, and the innovative small molecule potential candidate MOD-246. We shall see, but here is the latest, from Fierce Biotech:

…Merck is putting down $30 million upfront to buy Yale spinout Modifi Biosciences, a deal that includes a preclinical asset designed to take on the tough-to-treat brain cancer glioblastoma (GBM).

“We pitched to venture capitalists and the light switch would just go off when we talked about GBM,” Ranjit Bindra, M.D., Ph.D., Modifi co-founder and physician-scientist at the Yale School of Medicine, told Fierce Biotech in an interview. “You talk to a group like Merck—the light switch goes on.”

Modifi previously struggled to gain strong investor support, which Bindra attributed to a chaotic market and Modifi’s desire to stick to GBM, a relatively rare cancer. . . .

“DNA repair defects are a frequent hallmark of tumor cells and a major cause of resistance to cancer therapy,” David Weinstock, M.D., Ph.D., vice president of discovery oncology at Merck Research Laboratories, said in the release. “The talented Modifi Biosciences team has developed an innovative approach that we believe has potential for treating some of the most refractory cancer types.”

Merck and Modifi will next work on IND-enabling studies for MOD-246, with hopes of getting into the clinic by the end of next year, according to Bindra….

With five year survival in brain cancer still at only about 5%, this would be a very welcome development, should it extend survival by even a year or two. Now you know. Onward, to early vote, on Friday this week — and Buffs face Cincy at home, Saturday. Ever, onward!

नमस्ते

Fifty Sick — One Dead — After Trump Cosplay “Cooks” At McD’s…?

Of course, unlike the Powerline boys… I’m smart enough to know that an outbreak of horribly tainted quarter pounders – across ten states, sickening at least 50 (and killing one senior citizen in Colorado) — each at separate McDonald’s… probably isn’t entirely the work of one Tangerine Dotard.

But we (as “Well Rounded Men of Science”!) cannot rule his “cosplay fry cooking”… entirely out, either.

Turn-about is fair play, boys.

Grin!

Talking WNBA — And McD’s — Is All Intended To Obscure What Liz Cheney Is Doing; And What Dick Cheney… Is Doing…

The boys don’t want the GOP regulars to take even a moment, and reflect. Reflect on what has become of their [largely former] identities as supposedly… moral beings.

If asked, in a Confessional booth, or on their knees in the cathedral generally… to humbly reflect — reflect, on whether Tangerine and the MAGAts reflect their values… how will they answer?

That moment of self-awareness is what John and Paul and Scott and Steve want to bury before it might have a chance to rise from a smolder, to even a flickeringly small… flame.

For my money, EmptyWheel.net said it best this morning, in explaining why Kamala and Liz Cheney may be a potent “new Democratic vote finding” machine:

…[We must] give people who’ve come to hate that their own [GOP] party runs on dick stories and demeaning others, especially women and people of color, the courage to choose not to rejoin in that hatred out of partisan inertia or Republican self-identity.

Both Cheney and Harris have talked about power and powerlessness, and I can’t help but wonder if they’ve discussed Václav Havel’s essay on the power of the powerless while flying around together on a plane Liz’s father used to command, of the import of everyday people taking small acts of courage, the import of people like Dan refusing to join in Trump’s attacks on people that might include his five daughters (though, to be clear, Harris’ models of courage would come out of the Civil Rights movement, a culture in which she was raised).

Sykes described that Dan is a genuinely undecided voter. He sounded like a voter who had made his decision, but was asking for courage, was asking for Cheney and Harris to make it easier to sustain that courage. By 31 minutes into this town hall, he was even asking for, “something I could take with me to say, this sounds very good. We ought to at least listen to this.”

I don’t know whether it will work.

What I do know is that neither Harris nor Cheney are mistaking the enormity of the task, of trying to break the authoritarianism of a party that has overwhelmed voters with a blanket of disinformation and dehumanization.

They’re just trying to give people the courage to break out of a lifetime habit of voting for Republicans and instead to vote for the Constitution….

Indeed. And I for one am confident… it is working… one voter at a time, in private. A vote they will never admit to their own husband. But a vote they will… cast. And their daughters (and maybe even sons) will cast.

Cast for Kamala Harris.

Out.

Frothy Hard Right [And Mirengoff]… Angry At You Tube For “Promoting” Nail-Biter WNBA Final?!

So, last night the New York Liberty won their first ever WNBA Championship. And the internet only provider called YouTube promoted the thrilling OT Game Five — by having it run as a panel in most live sports events last night. Key: Internet only. [Just trying to build a larger, more inclusive sports-fan base. This is… an under-appreciated league having its moment, with Angel Reese and Caitlyn Clark.]

Of course, anyone could (and most people in fact DID!) tune the game in, on ESPN as well — i.e., regular cable TV.

But several whiny bitter old geezers, including churlish codger Paul, were offended that their “You-Tube only” soccer matches (for example) had a lower quarter screen that was keeping track of the WNBA championship game. So Mirengoff burped this up, overnight:

…I have nothing against women’s basketball. Although I don’t watch the WNBA, I do enjoy the last rounds of the Women’s NCAA championship. And last night’s WNBA contest — the decisive Game Five of the league’s title round — apparently turned out to be an overtime thriller.

But forcing people to have a WNBA game on their screen… that’s… YouTube deliberately did, seems like yet another manifestation of leftist Big Tech as Big Brother. Or, more to the point, Big Sister….

Geez-la-Weez. It is far more likely that these Boomers don’t know how to adjust the panels in YouTube Live.

And so, I realize these codgers on the far right are frustrated that their agenda has been co-opted/destroyed by Tangerine’s endless crime sprees, and thus they will be out on their ears in 14 days… but this is really a “you damn kids get off my lawn!” moment.

Do go outside and yell at the clouds, guys.

Or — better idea — rent a REAL life.

Cheers.

Rigby Nails The “Quew-Quew” — That Is Scott Johnson, On McD’s Street Theater — And Hinderaker, Generally…

 Excellent comment — so, I’ll just turn it over to Rigby:

[Scott Johnson’s] at it again today, going down the McDonald’s rabbit hole like he’s Jim Garrison investigating the JFK assassination. Hilarious stuff.

Meanwhile, Hinderaker looked in the mirror yesterday and thought he saw Democrats. Just about everything he asserts or complains about is either false or true of his side. I tried pointing this out in the comments, but my comments were quickly excised. Can’t have too many facts cluttering up John’s fever dreams. I’ll post my replies here, even though I’m preaching to the choir. John complains about a news story’s use of the expression “[Trump] acolytes,” muttering:

Did Barack Obama, Joe Biden or Kamala Harris ever have “acolytes”? Of course not.
Except, of course they do. It’s a very common journalistic expression. What a maroon. In the very next sentence, John goes on to complain:
Second, how has Trump “purged” the GOP? Has someone been kicked out of the party? Not that I know of.
How quickly he forgets. But his biggest howler is probably this one:
Everyone knows that it is Democrats, not Republicans, who try to steal elections.
Yeah, right.