Category: Uncategorized

IAVI Begins First Doses In “Open Label” Investigational Clinical Trial — Ebola Sudan Strain Vaccine, Deployed — In Kampala, Uganda…

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Well… it turns out that at least the first dosings in Kampala will not be the one under development at/by Soligenix.

The non-profit international alliance for vaccines, IAVI, will use a self-developed Sudan variant vaccine candidate with these first 44 contacts in Kampala. Here’s that story:

…The first participants have been vaccinated with an investigational Ebola Sudan vaccine candidate provided by IAVI, a nonprofit scientific research organization, as part of a World Health Organization (WHO)-led ring vaccination trial taking place at Makerere University Lung Institute in Kampala. WHO prioritized evaluation of IAVI’s candidate vaccine, which was already prepositioned in Uganda, as part of a global collaborative effort supporting the country’s Ebola outbreak response.

This is Uganda’s sixth outbreak of Ebola Sudan, which causes severe hemorrhagic fever disease with a case fatality rate of up to 50%. No licensed vaccines or therapeutics are available for Ebola Sudan, a Category A priority pathogen. Existing Ebola Zaire vaccines are not cross-protective for Ebola Sudan….

Onward, grinning into warmer (if rather gray) weather now… be excellent to one another.

नमस्ते

Merck Delivers Solid GAAP Results, But China HPV Franchise Sales Still Sluggish… Thus, An NYSE Dip.

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Not even remotely… surprising (if you are a regular reader, here). The NYSE decline is overwrought, though — to be sure.

So much so, that an eleven year old legacy graphic fits today’s news — nicely. Heh.

And my twelve month target remains at $130/share — due to the earnings juggernaut that is pembrolizumab (continuing to about 2032). But China is not vaccinating with Gardasil at the levels it used to, so the NYSE pre-market is showing a ~7% down-bubble (pre-market):

…Fourth-quarter adjusted earnings of $1.72 a share topped Wall Street’s call for $1.61, while global sales of $15.6 billion beat the FactSet consensus of $15.5 billion.

For the full year, earnings of $7.65 a share surpassed estimates of $7.53. Sales of $64.2 billion also beat expectations….

Now you know — and the decline in trading price will be a temporary dip — onward, grinning.

नमस्ते

Yawn. Scott Thinks The Black Sharpie Scribble Means… Anything?! Nope.

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Scott writes that Tangerine 2.0’s scribbles with a Sharpie (of last week, already!) are the “greatest policy changes in a century”.

Hilarious — and charmingly… naive.

They (aspire to be, at least) among the most radical. But they are not even putative “changes”.

All of the things he attempts (and Scott cheers), require new legislation from Congress, and Scott knows it.

As to this specific Sharpie scribble — a purported “change” to EEO laws (which Scott trumpets), there would need to be a revision to the 14th Amendment — and/or an overruling of about now 70 years of United States Supreme Court jurisprudence.

Read: not gonna’ happen.

But whatever son… Believe whatever you want.

He is, after all your “special ed” child.

And Now, In The Purported “No More Birthright” Case, There Will Also Be Public Audio Feeds, Via YouTube, This Thursday — I’ll Listen In…

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As promised, here it is — the Thursday motion for a preliminary injunction against Tangerine 2.0, that’s set for a hearing on February 6. [Tangerine claims he can eliminate specific sections of the Fourteenth Amendment — with one swipe of his black Sharpie. Poppycock.]

In any event, here is the public audio feed / YouTube listeners’ link, for that day and time:

…NOTICE TO THE PARTIES: The Court [in the Western District of Washington] will provide remote audio public access for the Preliminary Injunction Hearing set for 2/6/2025 at 10:00 AM in Courtroom 16206 before U.S. District Judge John C. Coughenour.

Remote public audio access has been authorized for the Preliminary Injunction Hearing in State of Washington, et al. v. Donald Trump, et al. Case number 2:25-cv-00127-JCC.

The hearing begins at 10:00 a.m. PST, on Thursday, February 6, 2025.

Audio access will be provided via YouTube at the following link:

https://youtube.com/live/jbFNoCkakV0?feature=share….

Now you know — he will get shellacked, again.

नमस्ते

Tangerine 2.0’s “Freeze” Argument… “Strains Credulity…” “The Court Can Think of Few Things More Disingenuous…” Ouch.

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The roundly-expected 30 page TRO, and reasoned opinion — of the able USDC Judge AliKhan is now published — minutes ago to the public docket, in full. Do read it all.

But let’s quote the nearly unprecedented take-down — of a sitting POTUS’s lack of candor, and thus — loss of credibility, with the courts. He’s lost the “presumption of good faith” most governmental actors are accorded in federal court. Ouch:

. . .Defendants are correct that courts of this circuit generally hesitate “to impute such manipulative conduct to a coordinate branch of government.” Pub. Citizen, Inc., 92 F.4th at 1128-29 (quoting Clarke v. United States, 915 F.2d 699, 705 (D.C. Cir. 1990) (en banc)). But this reluctance does not apply when the government defendant deliberately acts “in order to avoid litigation.” Alaska v. U.S. Dep’t of Agric., 17 F.4th 1224, 1229 (D.C. Cir. 2021) (quoting Am. Bar Ass’n v. Fed. Trade Comm’n, 636 F.3d 641, 648 (D.C. Cir. 2011)). Here, Defendants’ plea for a presumption of good faith rings hollow when their own actions contradict their representations. . . .

Within hours of OMB’s rescission, White House Press Secretary Leavitt announced that the rescission was to have no tangible effect on “the federal funding freeze.” Leavitt, X (formerly Twitter) (Jan. 29, 2025), https://perma.cc/99C4-5V6G. Moreover, she explained that the primary purpose of the rescission was “[t]o end any confusion created by the court’s injunction.” Id. That statement unambiguously reflects that the rescission was in direct response to this court’s issuance of an administrative stay on January 28.5 For Defendants to innocently claim that OMB’s post stay actions were merely a noble attempt to “end[] confusion,” ECF No. 26, at 8, strains credulity….

By rescinding the memorandum that announced the freeze, but “NOT… the federal funding freeze” itself, id., it appears that OMB sought to overcome a judicially imposed obstacle without actually ceasing the challenged conduct. The court can think of few things more disingenuous. Preventing a defendant from evading judicial review under such false pretenses is precisely why the voluntary cessation doctrine exists. The rescission, if it can be called that, appears to be nothing more than a thinly veiled attempt to prevent this court from granting relief….

Yep. That’s… a banger! You’ll need to get some ice on that Mr. Trump. Your back porch? It’s very bright… red, from the whuppin’ — one you richly earned, and deserved. Out — heh.

नमस्ते

And The Monthly Amazon Labor Item? From Quebec, Canada… And Timely. AMZN Abandons 2,000 Workers Immediately After They Vote In A Union.

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[I apologize — I’m a little late on this development, but Tangerine’s silly “flood the zone” efforts, down here in the lower 48 keep us hoppin’.]

Here’s that Bezos / carpet-bagger item: Wow. I gather Mr. Bezos brazenly fancies himself some form of a latter day Canadian railroad baron. Damn. [This would have been a second, and much larger, unionized facility in Quebec — see legacy graphic below, at right.]

I suppose he thinks he’s at least a lil’ like Elon — can do whatever he likes. He’s in for a rude awakening, on this. [And do consider his on record statements, about stepping away from inclusive workforce initiatives, here in the US.] Here’s The Hill, on it all:

…Last week, Amazon made a stunning decision to shutter its operations in Quebec, laying off approximately 2,000 workers. The reason? Workers at the company’s facilities in the Canadian province had just unionized.

This move — clear and brazen retaliation against organized labor — has reverberated beyond Canada’s borders. It’s not just a story about Quebec, Amazon or the 2,000 workers who now face sudden unemployment. It’s a global story — one with significant implications for the U.S. and the broader fight for workers’ rights….

To be clear, this is in no small measure why — at Raptors games played up north now, the Canadian fans have taken (since the end of January) to booing, when the US national anthem is played, after “Oh! Canada“. Holy smokes. Out.

नमस्ते

Hinderaker Doesn’t Realize All Tangerine Got From Mexico… Was What It Already Agreed To — With Mr. Biden. Sheesh.

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Hinderaker can’t spin this BS fast enough.

The Dow opened off 600 points — The Tangerine 2.0 morons panicked.

They blinked.

They accepted from Mexico exactly the same promises Mr. Biden secured, when Ms. Sheinbaum came to power there.

But Hinderaker declares it all some great Trump victory.

What an utterly feckless a-hole John is. This is not a nightclub act, John.

But the dotard (his boy) does think he’s producing a bad “un-” reality TV show, of some description.

And you are the pawn he uses… for this nonsense.

Cheers.

“The Tangerine 2.0 Freeze”… Is Frozen, Now… TWICE! The Able USDC Judge AliKhan Will Have A TRO In Place By 4:30 PM EST Today…

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She just said, on the live audio stream from DC, that the Council (the Plaintiffs) will put a TRO draft on the docket by 1:30 pm, and OMB can respond by 3:30 pm, local — but she will add her TRO to the Rhode Island TRO… by day’s end.

The clarity of Tangerine 2.0’s violations here have led to a very swift pair of appealable final orders. They stop Trump dead in his tracks. And there will be no stays of the these TROs.

Team Tangerine loses — completely — now he must file appeals to even begin his executive order process. Woot! Checks and balances… they work.

नमस्ते

Update: Tangerine 2.0 Blinks; Tries To Walk Back Canada’s “Misunderstanding” — Mexico Agrees To Cooperate On Fentanyl Interdiction: No Tariffs!

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This is precious. White House flaks are now saying that the Canadians “misunderstood” Mr. Trump’s Saturday orders. He’s trying to say — just as with the flip-flopped “Freeze” — people just. don’t. get. him. [This is not some goofy nightclub act. My God.]

The people at 1600 Penn. were clear: they launched a trade war. Canada responded. Tangerine is. . . a malign moron, nothing more.

Separately, Mexico has “agreed” to do what it was already doing with Mr. Biden’s cooperation, 2021 to 2024. And Tangerine has suspended those tariffs. This is a complete clown show — not governance, at all. Here’s the latest:

…”Canadians appear to have misunderstood the plain language of the executive order and they’re interpreting it as a trade war,” Hassett added….

[T]he president told reporters on Sunday they “have to balance out their trade, number one….”

What is not clear about that, man? You started a silly war. Now you are trying to say… “I was just… kidding“. That is… cra-cra.

And… almost trivially — Mr. Shumate’s underlings are getting shellacked in DC by the able USDC Judge Alikhan, on the Freeze (I am listening, live to the audio broadcast — but not gonna’ do a line by line liveblog — its just too clear that Tangerine 2.0, and the OMB lose here). This will end in a preliminary injunction, later today or tomorrow. What a silly cha-cha.

नमस्ते