On An About 2.5 Million Year Cycle, Mars Applies A “Warbler” — To Earth’s Orbit, Via Gravitational “Resonance”. And It Affects Our Deep Ocean Currents.

‘Tis in many many ways, almost unimaginably… poetic: the small hot red coal — moaning a gravitational song in the night, 140 million miles off… so very far away, and so faint. . . but when given enough time… into millions of years… that song is enough to stir our own deepest oceans of… life. Into whirlpools they tumble, over and over — across billions of years of time. Over the rocks from the basement of time, itself. Whoosh — that is amazing, to me.

And, of course, our own emissions are certainly a more profound, and immediate intervening variable — but it seems on about a 2.5 million year cycle, the orbit of Mars tends to give Earth a nudge — either elongating or rounding our orbital path around the Sun enough… to cause deep, deep whirlpools at the bottom of our oceans.

That in turn drives weather changes at the surface. Climate change, in short. The connection is born out in the sedimentary layers at the bottom of our oceans — of over 2 billion years. So… might there be a way to use this learning, to manage our own deep whirlpool creation mechanism, and help reverse the potential for collapse of the Atlantic Meridional Overturning Circulation? Perhaps — as it seems our own efforts at reducing emissions are falling woefully short.

Here’s that Earth / Planetary science story, from CNN on a Tuesday (and a teaser) — do go read it all:

…For the Earth, this interaction with Mars translates to periods of increased solar energy — meaning a warmer climate — and these warmer cycles correlate with more vigorous ocean currents, the report found.

While these 2.5 million-year cycles affect warming and ocean currents on Earth, they are natural climate cycles and not linked to the rapid heating the world is experiencing today as humans continue to burn planet-heating fossil fuels, said Dietmar Müller, professor of geophysics at the University of Sydney and a study co-author.

The authors describe these currents, or eddies, as “giant whirlpools” that can reach the bottom of the deep ocean, eroding the seafloor and causing large accumulations of sediments, like snowdrifts….

Again — the age of darkness (ignorance) seems to be receding almost everywhere, except in US (and Russian) politics. For our part, we remain optimistic that rational, principled common sense will prevail, come November — again. Grin.

नमस्ते

Despite Hinderaker’s Praise Of AL Sen. Katie Britt — It Seems Every Bit Of Her Story On Immigration Was A Lie.

Most of us would do better to just enjoy the SNL send up of her (it is about at the midpoint of the above clip) — she’s a walking punch line now. And we all well-knew the objective truth — and most of the GOP… have been complete strangers, for going on 20 years now.

Not only did this “story” occur under Bush 43 (i.e., 20 years ago!) — the woman has said she wasn’t taken by cartels, and was never trafficked in the US. She was a captive in Mexico only — and never crossed into the US under Biden, or Obama.

I N S A N E.

Add to all of this that Britt engages in truly junior high school level “fainting couch” acting — throughout the “GOP response”… and yep, the whole thing is a punch line. [But she’s Hinderaker’s “best girl”.]

And Tangerine is the butt of this joke.

Separately, almost as a footnote — did everyone catch that Trump is now for Tik-Tok, when he were agin’ it, for three years… while preznit? The guy claimed he had the power to ban TikTok nation-wide (thankfully, the ACLU among others won suits saying the First Amendment means what it says).

This is all going to be… great comedy, going into November.

Onward, grinning — as Mr. Biden has tonight decided that individuals with net worth of more than $100 million ought to pay at least 25% of their annual income as an absolute floor, in taxes. It will increase — but if a person makes $100 million in any year, s/he must pay no less than $25 million in federal income tax, should Mr. Biden (as I predict) win re-election.

F L A W L E S S.

Out.

Power Alley: Merck Closes M&A Deal; Now Owns Harpoon Therapeutics, For ~$650 Million…

The Hart Scott Rodino waiting period had expired about a week ago (without an added request from the Antitrust Division), and we mentioned the original inking of the purchase contract, here two months ago… but it is now put to bed. The assets are owned by Rahway, as of this morning, and the Harpoon stock symbol has stopped trading — on the NASDAQ.

Good news — but even so, as a cogent commenter pointed out in January, there have been some reports of off-target effects in the T-cell engager space (but the patients often face dire circumstances, with SCLC — without therapy).

Here’s the latest:

…[Rahway today completed] the acquisition of Harpoon Therapeutics, Inc. (Nasdaq: HARP). Harpoon is now a wholly-owned subsidiary of Merck, and Harpoon’s common stock will no longer be publicly traded or listed on the Nasdaq Stock Market.

“We continue to augment and diversify our oncology pipeline with innovative approaches to help people with cancer worldwide,” said Dr. Dean Y. Li, president, Merck Research Laboratories. “We are pleased to welcome our Harpoon colleagues to Merck and look forward to working together to advance a novel portfolio of T-cell engagers, including MK-6070.”

Harpoon’s lead candidate, MK-6070 (formerly known as HPN328), is a T-cell engager targeting delta-like ligand 3 (DLL3), an inhibitory canonical Notch ligand that is expressed at high levels in small cell lung cancer (SCLC) and neuroendocrine tumors. The safety, tolerability and pharmacokinetics of MK-6070 is currently being evaluated as monotherapy in a Phase 1/2 clinical trial (NCT04471727) in certain patients with advanced cancers associated with expression of DLL3. The study is also evaluating MK-6070 in combination with atezolizumab in certain patients with SCLC. In March 2022, the U.S. Food and Drug Administration (FDA) granted Orphan Drug Designation to MK-6070 for the treatment of SCLC….

Now you know — onward, grinning — sunny here!

[With our second (smaller) graphic, at left, we remind readers of an AI-powered diagnostics deal Merck has, in the oncology space.]

नमस्ते

Hinderaker’s Outright Lying / Advancing Dementia…

In an update / comment (largely unrelated to a Scott Johnson post) John just wrote:

“…Abraham Wyner testified as an expert witness on behalf of the defendants in the Michael Mann v. Mark Steyn case. We saw his testimony when we were in D.C. for the trial. Wyner presented a statistical analysis that showed that Mann’s famous hockey stick graph was, in fact, fraudulent. His analysis was persuasive and Wyner was a great witness, but unfortunately neither his testimony nor the other evidence presented by defendants was enough to [stave off a $1 million libel loss]. At least, not with a D.C. jury…”

Well, son… that’s because Steyn knowingly, and falsely so — called Dr. Mann a pedophile — repeatedly. The actual libel per se didn’t go to any climate science disagreement. None at all. [Some expert eh, Scott?]

But John read the DC verdict, and commented on it last month — in real time… so he well knows he’s lying, in the pull quote, above.

Yawn. Out.

As He’s Done For Over 20 Years Now, Hinderaker Once Again Falsely Labeled Someone “A Murderer”.

Back in July of 2000, Hinderaker falsely accused the a German bomber (10 injured or dead) of being… Muslim. [Later he changed even the location and date of the bombing he claimed was “Muslim-led” in his edits.]

He never apologized (the guy was a whyte radical German Neo-Nazi / Christian). But he did delete almost all of his original “story”; leaving only a link to the AP feed; and deleting a photo that he claimed (falsely) implicated a Muslim man. The man in the photo he had sourced at the time… turned out to be one of the bomber’s intended victims.

Again, John never apologized.

Last night, he falsely accused a Black teenager of “murder”. The whyte girl is not dead; the situation is tragic beyond words — but was the result of a school-yard brawl. Both are juveniles (age 15). The whyte girl is in the hospital — and expected to recover.

But Hinderaker wants the Black girl tried as an adult — for attempted murder.

Again, she’s 14 — and he wants life in prison — it was… a school fight, John.

Why? Because… she’s dared to beat a whyte girl for taunting her. Violence should never be the answer, but John hasn’t yet apologized for claiming falsely that the Whyte girl died in the attack.

Wow.

Just more of the same from John the race-baiter.

Out.

Gee — “Aren’t You Late… For… JAIL, Mr. Trump?”

Apparently, Tangerine took to his dying social media site tonight — to decry awards being given to [what he views as] politically correct causes… and actors.

But late in the broadcast, he renewed his feud with Jimmy Kimmel. So Kimmel decided to have fun with it, in near real time. He read Trump’s blurb, word for word… and then asked, incredulously…

“Gee… it is getting kinda’ late out East… Mr. President, aren’t you just a little late… for JAIL?!”

The crowd went… wild.

So… [except for about 5% of America] all Cheeto-lini achieved tonight… was to forcefully remind the rest of us that he is a petty, vain, thin-skinned bitter old man… and… that he is indeed… eventually headed to… prison.

Well done dotard… well done.

German Merck Suffers Setback — In Potential MS Candidate, Evobrutinib… So It Goes.

Thus Sanofi’s Aubagio® (the current standard of care, in MS) remains the top of the heap. Many pharmacos were looking at BTK inhibitors as the next generation — for MS therapy. It is fair to say that the Germans’ misses have chilled the entire space. But that — after all — is what science is about: trial and error; and then a redirecting of efforts based on the shared learnings.

Are Biogen, Novartis and Roche each re-evaluating their MS / BTK development programs? We shall soon see. In the meantime, here’s some of Fierce’s fine reporting on it all:

…It’s been a quick fall from grace for evobrutinib. Only months ago, Merck KGaA was outlining hopes for a major commercialization push for the BTK inhibitor — and now the German pharma has dropped the drug completely.

Merck told Fierce Biotech that the decision was made in response to the failure of evobrutinib to beat Sanofi’s Aubagio in two phase 3 multiple sclerosis (MS) clinical trials in December 2023. With Merck having pinned blockbuster hopes on the drug, the pair of failures sent shockwaves through the BTK inhibitor space at the time….

Up to the phase 3 readouts, the company had maintained sky-high hopes for the drug. As recently as November, Merck had outlined plans to support evobrutinib with a major commercialization push, telling investors that launch preparations would drive up costs starting in the fourth quarter and mulling whether to use a voucher to accelerate the FDA review.

On a call with analysts to discuss the earnings results, Merck CEO Belén Garijo admitted the BTK inhibitor’s failure “was no doubt a disappointment….”

Onward, smiling into the Sunday sunshine — for a brisk ride by the lake….

नमस्ते

Trivial — But Interesting, To Me, At Least… At The Main Site…

I guess I ought to invite my own… absence, more often. Heh.

Unlike at least the prior three years, this past one has seen my traffic spike as I take more extended, off-grid trips… almost exclusively for… pleasure.

But it truly is of no moment, since I never have — and never will — sell ads, or try to monetize my traffic. It is more a tool for gauging reader interest, in my case.

I gather (from my phone calendar) once in a great while, during one of the red trips — I had a quick lunch or afternoon biz meeting there somewhere in the middle, but mostly… I am out of pocket, and posting far less material during the red arrow intervals, at right.

So… I’d guess the data in 2023… says I am a man who has much about which to be… modest. Hah! Onward.

नमस्ते

Of Hinderaker’s Thinking: Fish Need… Bicycles?!

Welp. We all well now know that the GOP / MAGAts see the coming light, in the tunnel… and most of them are finally figuring it out — it is an oncoming freighter, under a head of steam. That’s Mr. Biden — post, the SOTU.

So John this morning clutches at straws.

He complains that Mr. Biden’s speech started late, due to a protest on the streets of DC tying up traffic for about 10 minutes.

Okay. Whatever — the First Amendment is still… a thing, John.

But he goes on to equate this 10 minute tie up to… wait for it: January 6 2021.

You know, when ruffians stormed the Capitol, killed people in the process, and tried to find and hang the GOP Veep, all on the “Cheeto-lini’s” exhortations to stop his winning opponent from being certified as the new Commander in Chief.

Yes. Those two things are… fish and bicycles, John.

Your senility is showing, man.

Out.